Results 41 to 50 of about 47,037 (210)

Utilization of ursolic acid methyl ester in the treatment of Streptococcus pyogenes in Nile tilapia, concerning physiological, genetic, immune-oxidative, stress, and neuro-ethological parameters

Aquaculture Reports
The present work is an innovative approach for application the Streptomyces misakiensis S. misakiensis metabolite called ursolic acid methyl ester (UAME) in treating Streptococcus pyogenes of Nile tilapia.
Rewan Abdelaziz, Mona Abd El khalek Salem, Walaa El-Houseiny, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Heba H. Mahboub, Shimaa Zayed, Reham A. Abd El-Wahab, Basma A. Elshafey, Simon J. Davies, Amany Omar Selim   +10 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo

Frontiers in Immunology, 2019
Streptococcus pyogenes is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis.
Anna Hafner, Anna Hafner, Ulrike Kolbe, Isabel Freund, Virginia Castiglia, Pavel Kovarik, Tanja Poth, Franziska Herster, Markus A. Weigand, Alexander N. R. Weber, Alexander H. Dalpke, Alexander H. Dalpke, Tatjana Eigenbrod   +12 more
doaj   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye

Journal of Infection and Public Health
Background: Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S.
Nihan Ünübol, Nese Caglayan, Sinan Cebeci, Yeşim Beşli, Banu Sancak, Neval Yurttutan Uyar, Siavosh Salmanzadeh Ahrabi, Masoud Alebouyeh, Tanıl Kocagöz   +8 more
doaj   +1 more source

StreptInCor: a candidate vaccine epitope against S. pyogenes infections induces protection in outbred mice. [PDF]

PLoS ONE, 2013
Infection with Streptococcus pyogenes (S. pyogenes) can result in several diseases, particularly in children. S. pyogenes M protein is the major virulence factor, and certain regions of its N-terminus can trigger autoimmune sequelae such as rheumatic ...
Edilberto Postol, Raquel Alencar, Fabio T Higa, Samar Freschi de Barros, Lea M F Demarchi, Jorge Kalil, Luiza Guilherme   +6 more
doaj   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Inactivation of the Rgg2 transcriptional regulator ablates the virulence of Streptococcus pyogenes. [PDF]

PLoS ONE, 2014
Streptococcus pyogenes adapts to different niches encountered in the human host via the activity of numerous regulatory proteins including the Rgg family of transcriptional regulators. The S.
Anastasia A Zutkis, Srivishnupriya Anbalagan, Michael S Chaussee, Alexander V Dmitriev   +3 more
doaj   +1 more source