Results 51 to 60 of about 131,599 (329)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Enteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies [PDF]

, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Barlow, A Pini Prato, A Zani, AG Baynash, AG Catto-Smith, AJ Burns, AJ Burns, Alan J. Burns, AS Wallace, C Caldwell, C Kalcheim, C Laranjeira, CH Knowles, Conor McCann, D Natarajan, Dipa Natarajan, DM Rodrigues, E Panza, Ellen Binder, GE Boeckxstaens, H Tsuji, HM Pallari, J Amiel, Jean-Marie Delalande, Julie Cooper, L Becker, L Ludman, M Hanani, M Metzger, Mara Cananzi, MC Nunes, MD Gershon, Mirella Dottori, MP Sanchez, MT Liu, N Bondurand, N Nagoshi, N Thapar, Nikhil Thapar, NR Druckenbrod, PS Danielian, R Hotta, R Hotta, R Zufferey, Rania Kronfli, RC Mifflin, RM Lindley, S Almond, S Bixby, S Hetz, S Srinivas, S Theocharatos, SJ Conway, SJ Howe, SJ McKeown, TA Heanue, TP Rothman, U Rauch, V Sasselli, X Jiang, Y Matsuda, YH Tsai   +61 more
core   +6 more sources

Directional Liquid Transport Enabled pH‐Responsive Hierarchical Composite for Enhanced Wound Healing

Advanced Healthcare Materials, EarlyView.
A hierarchical composite with a gradient architecture transitioning from hydrophobic to hydrophilic layers integrates diode‐like liquid transport, efficient water absorption, breathability, and mechanical robustness. This device enables a multifunctional therapeutic platform with pH‐responsive dual‐drug release, providing synergistic anti‐inflammatory ...
Baolin Wang, Li‐Fang Zhu, Yuna Lang, Siyi Zhang, Fei Chen, Ming‐Wei Chang   +5 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Nonparametric 3D map of the IGM using the Lyman-alpha forest

, 2014
Visualizing the high-redshift Universe is difficult due to the dearth of available data; however, the Lyman-alpha forest provides a means to map the intergalactic medium at redshifts not accessible to large galaxy surveys.
Cisewski, Jessi, Croft, Rupert A. C., Freeman, Peter E., Genovese, Christopher R., Khandai, Nishikanta, Ozbek, Melih, Wasserman, Larry   +6 more
core   +1 more source

Biphenotypic Sinonasal Sarcoma-Case Report and Review of Clinicopathological Features and Diagnostic Modalities. [PDF]

, 2019
Background Biphenotypic sinonasal sarcoma is a recently described malignancy showing dual differentiation with both myogenic and neural elements. Due to its histologic similarities to other sinonasal malignancies, it is a diagnostic challenge.
Chitguppi, Chandala, Collura, Kaitlin, Curtis, Mark, Koszewski, Ian, Nyquist, Gurston G., Rabinowitz, Mindy R., Rosen, Marc   +6 more
core   +2 more sources

Calorimetry for low-energy electrons using charge and light in liquid argon [PDF]

, 2020
Precise calorimetric reconstruction of 5–50 MeV electrons in liquid argon time projection chambers (LArTPCs) will enable the study of astrophysical neutrinos in DUNE and could enhance the physics reach of oscillation analyses.
Carey, Robert M., Kearns, Edward
core   +1 more source

Hydrogelation via Supramolecular Copolymerization of Structural Water within Adaptive Metal–Organic Fibers

Advanced Materials, EarlyView.
Structural water is harnessed as an active co‐monomer to drive supramolecular polymerization in bulk water. Zinc(II) Salphen complexes confine water molecules to form hollow, metal–organic nanofibers that assemble into adaptive hydrogels with thermoresponsive mechanics and selective chiral recognition.
Merlin R. Stühler, Hesam Makki, Tarek Hilal, Debsena Chakraboty, Mathias Dimde, Kai Ludwig, Rainer Haag, Sabine Rosenfeldt, Dorothee Silbernagl, Andreas Schäfer, Alex J. Plajer   +10 more
wiley   +1 more source

Two‐Photon Polymerized Microvascular Environments for Multicellular Modeling of the Blood–Brain Tumor Barrier

Advanced Materials Technologies, EarlyView.
Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin, Sayba Z. Chowdhury, Maurice de Wit, Rania Head, Kiki Bals, Erwin Brosens, Marvin M. van Luijn, Hayri E. Balcioglu, Angelo Accardo, Pim J. French   +9 more
wiley   +1 more source

A case of large diffuse cutaneous neurofibroma masquerading as plexiform variant: Diagnostic challenges [PDF]

Journal of Krishna Institute of Medical Sciences University
Diffuse Cutaneous Neurofibroma (DCN) is an infrequently encountered clinical entity that can be challenging to diagnose due to its variable clinical presentation, radiological findings, and histopathological features.
Shivani S Rao , Ranjana S Ranade
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