Results 171 to 180 of about 40,904 (213)
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S100b expression in and effects on microglia
Glia, 2001We evaluated the intracellular and extracellular biological role of S100B protein with respect to microglia. S100B, which belongs to the multigenic family of Ca2+-binding proteins, is abundant in astrocytes where it is found diffusely in the cytoplasm and is associated with membranes and cytoskeleton constituents.
Guglielmo Sorci +2 more
exaly +5 more sources
S100B in neuropathologic states: The CRP of the brain?
Journal of Neuroscience Research, 2007AbstractIn recent years there has been a proliferation of interest in the brain‐specific protein S100B, its many physiologic roles, and its behaviour in various neuropathologic conditions. Since the mid‐1960s, its wide variety of intracellular and extracellular activities has been elucidated, and it has also been implicated in an increasing number of ...
Jon Sen, Antonio Belli
exaly +3 more sources
Psychiatry and Clinical Neurosciences, 2013
The research for peripheral biological markers of schizophrenia, although abundant, has been unfruitful. In the last 2 decades, the S100B protein has made its own room in this area of research. S100B is a calcium‐binding protein that has been proposed as a marker of astrocyte activation and brain dysfunction.
Silvia, Yelmo-Cruz +2 more
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The research for peripheral biological markers of schizophrenia, although abundant, has been unfruitful. In the last 2 decades, the S100B protein has made its own room in this area of research. S100B is a calcium‐binding protein that has been proposed as a marker of astrocyte activation and brain dysfunction.
Silvia, Yelmo-Cruz +2 more
openaire +2 more sources
Design of Inhibitors for S100B
Current Topics in Medicinal Chemistry, 2005S100B interacts with the p53 protein in a calcium-dependent manner and down-regulates its function as a tumor suppressor. Therefore, inhibiting the S100B-p53 interaction represents a new approach for restoring functional wild-type p53 in cancers with elevated S100B such as found in malignant melanoma.
Joseph, Markowitz +4 more
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Clinica Chimica Acta, 2003
Follow-up studies have shown that the vast majority of neurological abnormalities present during childhood can have a prenatal or perinatal origin. It is relevant, therefore, to investigate the timing of adverse insults in the search for measures of prevention. However, such knowledge is still incomplete and subject to debate.
Michetti, Fabrizio, Gazzolo, Diego
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Follow-up studies have shown that the vast majority of neurological abnormalities present during childhood can have a prenatal or perinatal origin. It is relevant, therefore, to investigate the timing of adverse insults in the search for measures of prevention. However, such knowledge is still incomplete and subject to debate.
Michetti, Fabrizio, Gazzolo, Diego
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Computational screening and design of S100B ligand to block S100B–p53 interaction
Journal of Molecular Graphics and Modelling, 2009The binding of S100B to p53 disables the biological function of p53 as a tumor suppressor and thus causes cancer. It is very important to explore the interaction between S100B and p53 and to develop inhibitors to block the interaction in anti-cancer development.
John L, Whitlow +4 more
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S100B in Schizophrenic Psychosis
2004Recent findings have strengthened the hypothesis that a dysfunction of neuronal synapses and dendrites is relevant for the pathogenesis of schizophrenia. It might be present during neurodevelopment as well as in degenerative and regenerative processes of the mature brain.
Matthias, Rothermundt +2 more
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S100B protein in benzodiazepine overdose
Emergency Medicine Journal, 2008Severe benzodiazepine overdose can result in coma and respiratory depression that might cause brain hypoxia, necrosis and delayed post-anoxic leucoencephalopathy with permanent neurological sequelae. The aim of this study was to assess the possible role of S100B, a structural protein of astroglial cells, as a biochemical marker of brain injury in acute
J, Ambrozic +3 more
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S100B in brain damage and neurodegeneration
Microscopy Research and Technique, 2003AbstractS100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and in vivo animal experiments to understand S100B's roles in cellular energy metabolism, cytoskeleton modification, cell proliferation, and differentiation.
Matthias, Rothermundt +3 more
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S100B protein in neurodegenerative disorders
cclm, 2011Abstract“Classic” neurodegenerative disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis share common pathophysiological features and involve progressive loss of specific neuronal populations, axonal or synaptic loss and dysfunction, reactive astrogliosis, and reduction in myelin.
Steiner, J. +3 more
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