Results 181 to 190 of about 40,904 (213)

Serum S100B Levels in Melanoma

2019
Malignant melanoma is a cancer with increasing incidence worldwide with relevant socioeconomic impact. Despite progress in prevention and early detection, it is one of the most lethal forms of skin cancer. Therefore it is urgent need to identify suitable biomarkers in order to improve early diagnosis, precise staging, and prognosis, as well as for ...
Frauchiger, Anna Lisa, Dummer, Reinhard, Mangana, Joanna   +2 more
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Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009
AbstractSeveral lines of evidence suggest an important role of the S100B protein and its coding gene in different neuropathological and psychiatric disorders like dementia, bipolar affective disorders and schizophrenia. To clarify whether a direct link exists between gene and gene product, that is, whether S100B variants directly modulate S100B serum ...
Christa, Hohoff, Gerald, Ponath, Christine M, Freitag, Florian, Kästner, Petra, Krakowitzky, Katharina, Domschke, Katja, Koelkebeck, Frank, Kipp, Christof, von Eiff, Jürgen, Deckert, Matthias, Rothermundt   +10 more
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The ischemic rat heart releases S100B

Life Sciences, 2005
S100B is an astrocytic protein assessed in cerebrospinal fluid and serum as a biochemical marker of cerebral injuries. However, increasing evidences suggest the influence of extra cerebral sources on its serum levels. Since it was reported that the injured myocardium expresses S100B, we investigated whether the isolated heart releases this protein. The
Guilherme S, Mazzini, Débora V, Schaf, Alvaro R, Oliveira, Carlos A, Gonçalves, Adriane, Belló-Klein, Solange, Bordignon, Ricardo S, Bruch, Guilherme F, Campos, Dalton V, Vassallo, Diogo O, Souza, Luis V C, Portela   +10 more
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S100B and the influence of seasonal variation

Scandinavian Journal of Clinical and Laboratory Investigation, 2016
Background A blood test for S100B can be used to rule out intracranial complications after minor head injury and thereby reduce the need for computed tomography (CT) examinations. The aim of this study was to investigate the clinical importance of a possible influence of seasonal variation on S100B. Methods The individual seasonal variation of S100B in
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S100B: a multifunctional role in cardiovascular pathophysiology

Amino Acids, 2010
S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions. S100B is induced in the myocardium of human subjects and an experimental rat model following myocardial infarction. Forced expression of S100B in neonatal rat myocyte cultures, and high level expression of S100B in transgenic mice hearts and ...
James N, Tsoporis, Forough, Mohammadzadeh, Thomas G, Parker   +2 more
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Enhanced epileptogenesis in S100B knockout mice

Molecular Brain Research, 2002
S100B is a small calcium- and zinc-binding protein expressed by astrocytes in the central nervous system. Here, we examined the role of S100B in epileptogenesis using an amygdala kindling paradigm comparing S100B knockout mice with their wild-type counterparts.
Richard H, Dyck, Isaac I, Bogoch, Alexander, Marks, Neal R, Melvin, G Campbell, Teskey   +4 more
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Theoretical study on binding of S100B protein

Journal of Molecular Modeling, 2007
S100B protein is one of the factors involved in the down-regulation of tumor suppressor protein p53, a transcription activator that signals for cycle arrest and apoptosis. As the inactivation of normal p53 functions is found in over half of human cancers, restoration of normal p53 functions through the destruction or prevention of S100B--p53 complexes ...
GIELDON ARTUR, MORI M, DEL CONTE REBECCA
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Serum Concentrations of s100b and NSE in Migraine

Headache: The Journal of Head and Face Pain, 2009
Background.— The protein s100b indicates astrocytal damage as well as dysfunction of the blood‐brain barrier (BBB), and neuron‐specific enolase (NSE) is regarded as a marker for neuronal cell loss. Recently, s100b was shown to be a potentially useful marker for migraine in children.
Michael, Teepker, Karoline, Munk, Veit, Mylius, Anja, Haag, Jens C, Möller, Wolfgang H, Oertel, Karsten, Schepelmann   +6 more
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S100B/RAGE-dependent chemoattraction of microglia

Italian Journal of Anatomy and Embryology, 2010
Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement ...
Bianchi, Roberta, Kastrisianaki, Eirini, Giambanco, Ileana, Donato, Rosario   +3 more
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S100B protein stimulates calcineurin activity

NeuroReport, 2004
S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity of both purified and cytoskeletal ...
Rodrigo B, Leal, Juliana K, Frizzo, Francine, Tramontina, Sabine, Fieuw-Makaroff, Larisa, Bobrovskaya, Peter R, Dunkley, Carlos-Alberto, Gonçalves   +6 more
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