Results 21 to 30 of about 48,304 (243)

Potential conformational heterogeneity of p53 bound to S100B(ββ) [PDF]

, 2013
Citation: McDowell, C., Chen, J., & Chen, J. (2013). Potential conformational heterogeneity of p53 bound to S100B(ββ). Journal of Molecular Biology, 425(6), 999- 1010.The negative regulatory domain (NRD) of the p53 tumor suppressor is intrinsically ...
McDowell, Chester, Chen, Jianhan, Chen, Jianlin   +2 more
core   +1 more source

S100B and S100B autoantibody as biomarkers for early detection of brain metastases in lung cancer [PDF]

Translational Lung Cancer Research, 2016
S100B is an astrocytic protein that enters the blood stream when there is disruption of the blood-brain barrier (BBB). Over time, antibodies against S100B develop in the sera of patients who experience persistent or repeated BBB disruptions. We explored the use of serum S100B protein and S100B autoantibodies for the detection of brain metastasis in ...
Humberto, Choi, Vikram, Puvenna, Chanda, Brennan, Shamseldeen, Mahmoud, Xiao-Feng, Wang, Michael, Phillips, Damir, Janigro, Peter, Mazzone   +7 more
openaire   +2 more sources

S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response

Frontiers in Cellular and Infection Microbiology, 2021
The involvement of the enteric nervous system, which is a source of S100B, in Clostridioides difficile (C. difficile) infection (CDI) is poorly understood although intestinal motility dysfunctions are known to occur following infection.
Deiziane V. S. Costa, Deiziane V. S. Costa, Deiziane V. S. Costa, Vivaldo Moura-Neto, David T. Bolick, Richard L. Guerrant, Jibraan A. Fawad, Jae H. Shin, Pedro H. Q. S. Medeiros, Solanka E. Ledwaba, Glynis L. Kolling, Conceição S. Martins, Venkat Venkataraman, Venkat Venkataraman, Cirle A. Warren, Gerly A. C. Brito, Gerly A. C. Brito   +16 more
doaj   +1 more source

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]

, 2012
Peer ...
Maetzler, Walter, Berg, Daniela, Teismann, Peter, Mounsey, Ross Brian, Vukovic, Zvonimir, Synofzik, Matthis, Mustafa, Sarah, Itohara, Shigeyoshi, Sathe, Kinnari, Schulte, Claudia, Martin, Heather Louise, Lang, Johannes, Fleckenstein, Corinna, Lang, Johannes Dominik   +13 more
core   +1 more source

S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate

Metabolites, 2023
S100B is a calcium-binding protein produced and secreted by astrocytes in response to various extracellular stimuli. C6 glioma cells are a lineage commonly employed for astroglial studies due to the expression of astrocyte specific markers and behavior ...
Nicholas Guerini Selistre, Leticia Rodrigues, Barbara Carolina Federhen, Vitor Gayger-Dias, Jéssica Taday, Krista Mineia Wartchow, Carlos-Alberto Gonçalves   +6 more
doaj   +1 more source

PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation

Journal of Neuroinflammation, 2010
Background Numerous studies have reported that increased expression of S100B, an intracellular Ca2+ receptor protein and secreted neuropeptide, exacerbates Alzheimer's disease (AD) pathology. However, the ability of S100B inhibitors to prevent/reverse AD
Young Keith A, Holcomb Leigh, Roltsch Emily, Marks Alexander, Zimmer Danna B   +4 more
doaj   +1 more source

Time-Dependent Internalization of S100B by Mesenchymal Stem Cells via the Pathways of Clathrin- and Lipid Raft-Mediated Endocytosis

Frontiers in Cell and Developmental Biology, 2021
Mesenchymal stem cells (MSCs) are promising tools for cancer therapy, but there is a risk of malignant transformation in their clinical application.
Ying Zhang, Ying Zhang, Ying Zhang, Ying Zhang, Jing Zhu, Jing Zhu, Jing Zhu, Jing Zhu, Hao Xu, Hao Xu, Hao Xu, Hao Xu, Qin Yi, Qin Yi, Qin Yi, Qin Yi, Liang Yan, Liang Yan, Liang Yan, Liang Yan, Liang Ye, Liang Ye, Liang Ye, Liang Ye, Xinyuan Zhang, Xinyuan Zhang, Xinyuan Zhang, Xinyuan Zhang, Min Xie, Min Xie, Min Xie, Min Xie, Bin Tan, Bin Tan, Bin Tan, Bin Tan   +35 more
doaj   +1 more source

Subject-specific increases in serum S-100B distinguish sports-related concussion from sports-related exertion. [PDF]

PLoS ONE, 2014
The on-field diagnosis of sports-related concussion (SRC) is complicated by the lack of an accurate and objective marker of brain injury.To compare subject-specific changes in the astroglial protein, S100B, before and after SRC among collegiate and semi ...
Karin Kiechle, Jeffrey J Bazarian, Kian Merchant-Borna, Veit Stoecklein, Eric Rozen, Brian Blyth, Jason H Huang, Samantha Dayawansa, Karl Kanz, Peter Biberthaler   +9 more
doaj   +1 more source

The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing—Remitting Multiple Sclerosis Mouse Model

Cells, 2020
S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated.
Gabriele Di Sante, Susanna Amadio, Beatrice Sampaolese, Maria Elisabetta Clementi, Mariagrazia Valentini, Cinzia Volonté, Patrizia Casalbore, Francesco Ria, Fabrizio Michetti   +8 more
doaj   +1 more source

Elevated Blood S100B Levels in Patients With Migraine: A Systematic Review and Meta-Analysis

Frontiers in Neurology, 2022
Background:In recent years, a growing number of researches indicate that S100B may act in migraine, but the relationship between S100B and migraine remains controversial.
Chaojia Chu, Rui Zhong, Mengtan Cai, Nan Li, Weihong Lin   +4 more
doaj   +1 more source