Results 31 to 40 of about 40,904 (213)

S100A1 and S100B interactions with annexins

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000
Members of the annexin protein family interact with members of the S100 protein family thereby forming heterotetramers in which an S100 homodimer crossbridges two copies of the pertinent annexin. Previous work has shown that S100A1 and S100B bind annexin VI in a Ca(2+)-dependent manner and that annexin VI, but not annexin V, blocks the inhibitory ...
GARBUGLIA, Marisa, VERZINI, Marco, HOFMANN A, HUBER R, DONATO, Rosario Francesco   +4 more
openaire   +5 more sources

Serum Glial Fibrillary Acidic Protein and S100B Profiles in Severity and Outcome Assessment of Moderate and Severe Head Injury Patients in India

Current Medical Issues
Background Traumatic brain injury (TBI) is a significant global health issue, with India witnessing approximately 150,000 deaths and 50,000 TBI-related fatalities annually. Severity is classified as mild, moderate, or severe using the Glasgow Coma Scale (
Arpana Singh, A. S. Ramesh, Prashant Shankarrao Adole, Pooja Verma   +3 more
doaj   +1 more source

Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain

Frontiers in Molecular Neuroscience, 2018
Neuronal metal ions such as zinc are essential for brain function. In particular synaptic processes are tightly related to metal and protein homeostasis, for example through extracellular metal-binding proteins.
Simone Hagmeyer, Simone Hagmeyer, Simone Hagmeyer, Joana S. Cristóvão, John J. E. Mulvihill, John J. E. Mulvihill, Tobias M. Boeckers, Cláudio M. Gomes, Andreas M. Grabrucker, Andreas M. Grabrucker, Andreas M. Grabrucker   +10 more
doaj   +1 more source

The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling.

PLoS ONE, 2021
S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling. Our
Milad J Alasady, Alexander R Terry, Adam D Pierce, Michael C Cavalier, Catherine S Blaha, Kaylin A Adipietro, Paul T Wilder, David J Weber, Nissim Hay   +8 more
doaj   +1 more source

The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng)

Klinik Psikiyatri Dergisi, 2021
INTRODUCTION[|]In hypertensive people, some biochemical parameters that are associated with oxidative stress and endothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensification of clinical symptoms of the ...
Aslı Kazğan, Sevda Korkmaz, Sevler Yildiz, Hasan Korkmaz, Selda Telo, Murad Atmaca   +5 more
doaj   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Correlation between cerebral biomarkers and optic nerve sheath diameter in patients with severe preeclampsia

Hypertension in Pregnancy, 2021
Objective: To examine the correlation between plasma cerebral biomarkers (S100B and neuron-specific enolase (NSE)) and ultrasonographic optic-nerve-sheath-diameter (ONSD) in preeclampsia.
Gabrijela Brzan Simenc, Jana Ambrozic, Josko Osredkar, Ksenija Gersak, Miha Lucovnik   +4 more
doaj   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

S100B milk concentration in mammalian species

Frontiers in Bioscience, 2009
S100B is a neurotrophic protein detectable in biological fluids and in human milk. Since there are several maternal-neonatal conditions requiring the administration of animal milks the aim of the present study was to quantify S100B in milk from different mammalian species and to compare protein's concentration among human and mammalian milks.
Galvano, F, Frigiola, A, Gagliardi, L, Ciotti, S, Bognanno, M, Iacopino, Am, Nigro, F, Tina, Gl, Cavallaro, D, Mussap, M, Piva, A, Grilli, E, Michetti, Fabrizio, Gazzolo, D.   +13 more
openaire   +6 more sources

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source