Results 51 to 60 of about 40,904 (213)

Association of S100B Serum Levels with Metabolic Syndrome and its Components

Acta Médica Portuguesa, 2018
Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome. Materials and Methods: In this study, 44 patients
Sorayya Kheirouri, Elham Ebrahimi, Mohammad Alizadeh   +2 more
doaj   +1 more source

Molecular Determinants of S100B Oligomer Formation

PLoS ONE, 2011
S100B is a dimeric protein that can form tetramers, hexamers and higher order oligomers. These forms have been suggested to play a role in RAGE activation.Oligomerization was found to require a low molecular weight trigger/cofactor and could not be detected for highly pure dimer, irrespective of handling. Imidazol was identified as a substance that can
Eva Thulin, Tõnu Kesvatera, Sara Linse
openaire   +4 more sources

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Gender differences in plasma S100B levels of patients with major depressive disorder

BMC Psychiatry
Background Low concentrations of S100B have neurotrophic effects and can promote nerve growth and repair, which plays an essential role in the pathophysiological and histopathological alterations of major depressive disorder (MDD) during disease ...
Yifan Wu, Yihui Lu, Lingtao Kong, Yu Xie, Wen Liu, Anqi Yang, Kaiqi Xin, Xintong Yan, Longhai Wu, Yilin Liu, Qianying Zhu, Yang Cao, Yifang Zhou, Xiaowei Jiang, Yanqing Tang, Feng Wu   +15 more
doaj   +1 more source

Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

JCRPE, 2019
Objective:Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are markers of different neurological disorders. The aim was to investigate the relationship between NSE and S100B serum concentrations and the severity of diabetic ...
Hatem Hamed Elshorbagy, Naglaa Fathy Barseem, Akram Elshafey Elsadek, Ashraf Hamed Al-shokary, Yehia Hamed Abdel Maksoud, Sameh Elsayed Abdulsamea, Iman M. Talaat, Hany Abdelaziz Suliman, Naglaa M. Kamal, Waleed E. Abdelghani, Sanaa Mohammed Azab, Dalia Mohamed Nour El Din   +11 more
doaj   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Serum S100B protein is specifically related to white matter changes in schizophrenia

Frontiers in Cellular Neuroscience, 2016
Background: Schizophrenia can be conceptualized as a form of dysconnectivity between brain regions. To investigate the neurobiological foundation of dysconnectivity, one approach is to analyze white matter structures, such as the pathology of fiber ...
Berko eMilleit, Berko eMilleit, Stefan eSmesny, Matthias eRothermundt, Matthias eRothermundt, Christoph ePreul, Matthias L. Schroeter, Matthias L. Schroeter, Christof evon Eiff, Christof evon Eiff, Gerald ePonath, Gerald ePonath, Christine eMilleit, Christine eMilleit, Heinrich eSauer, Christian eGaser, Christian eGaser   +16 more
doaj   +1 more source

The S100B/RAGE Axis in Alzheimer's Disease [PDF]

Cardiovascular Psychiatry and Neurology, 2010
Increasing evidence suggests that the small EF-hand calcium-binding protein S100B plays an important role in Alzheimer's disease. Among other evidences are the increased levels of both S100B and its receptor, the Receptor for Advanced Glycation Endproducts (RAGEs) in the AD diseased brain.
Estelle Leclerc, Emmanuel Sturchler, Stefan W. Vetter   +2 more
openaire   +2 more sources

Serum S100B levels in patients with depression

Indian Journal of Psychiatry, 2019
Background: The biochemical basis of depression has been related to blood–brain barrier (BBB) allowing/restricting a number of components to enter the brain milieu from the peripheral plasma milieu. S100B has been associated with BBB damage and is used as a marker of its integrity.
Arora, Parul, Sagar, Rajesh, Mehta, Manju, Pallavi, Pooja, Sharma, Subhadra, Mukhopadhyay, Asok Kumar   +5 more
openaire   +2 more sources