Results 71 to 80 of about 48,304 (243)

Gender differences in plasma S100B levels of patients with major depressive disorder

BMC Psychiatry
Background Low concentrations of S100B have neurotrophic effects and can promote nerve growth and repair, which plays an essential role in the pathophysiological and histopathological alterations of major depressive disorder (MDD) during disease ...
Yifan Wu, Yihui Lu, Lingtao Kong, Yu Xie, Wen Liu, Anqi Yang, Kaiqi Xin, Xintong Yan, Longhai Wu, Yilin Liu, Qianying Zhu, Yang Cao, Yifang Zhou, Xiaowei Jiang, Yanqing Tang, Feng Wu   +15 more
doaj   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Serum S100B protein is specifically related to white matter changes in schizophrenia

Frontiers in Cellular Neuroscience, 2016
Background: Schizophrenia can be conceptualized as a form of dysconnectivity between brain regions. To investigate the neurobiological foundation of dysconnectivity, one approach is to analyze white matter structures, such as the pathology of fiber ...
Berko eMilleit, Berko eMilleit, Stefan eSmesny, Matthias eRothermundt, Matthias eRothermundt, Christoph ePreul, Matthias L. Schroeter, Matthias L. Schroeter, Christof evon Eiff, Christof evon Eiff, Gerald ePonath, Gerald ePonath, Christine eMilleit, Christine eMilleit, Heinrich eSauer, Christian eGaser, Christian eGaser   +16 more
doaj   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

S100B + A1 CELISA: A Novel Potency Assay and Screening Tool for Redifferentiation Stimuli of Human Articular Chondrocytes. [PDF]

, 2017
During monolayer expansion, a necessary step in autologous chondrocyte implantation, human articular chondrocytes (HAC) dedifferentiate and lose their capacity to produce stable hyaline cartilage. Determining HAC potency and learning how to trigger their
Dobrila Nesic, Nesic, Dobrila, Jose Diaz‐Romero, Kürsener, Sibylle, Sandro Kohl, Sibylle Kürsener, Diaz Romero, Jose, Kohl, Sandro   +7 more
core   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Correlation Between BMI and S100B.

, 2013
Given the expression of S100B in adipocytes, we investigated the relationship between fat content and S100B levels using 200 subjects. No correlation was found between BMI and S100B levels.
Vincent Fazio (16280), Qingshan Teng (361887), Peter Biberthaler (361888), Damir Janigro (4975), Luca Cucullo (4970), Nancy Pham (361886), Jeffrey J. Bazarian (361889)   +6 more
core   +1 more source

Acute S100B in serum is associated with cognitive symptoms and memory performance 4 months after paediatric mild traumatic brain injury [PDF]

, 2015
OBJECTIVE This study explored whether acute serum marker S100B is related with post-concussive symptoms (PCS) and neuropsychological performance 4 months after paediatric mild traumatic brain injury (mTBI).
Leichtle, Alexander Benedikt, Studer, Martina, Goeggel Simonetti, Barbara, Heinks Maldonado, Theda, Steinlin, Maja, Joeris, Alexander, Berger, Steffen Michael   +6 more
core   +2 more sources

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Astrocytic Biomarkers in Epilepsy: A Critical Review on Clinical Utility and Mechanistic Implications

Frontiers in Bioscience-Landmark
Epilepsy is one of the most common neurological disorders in both children and adults, characterized by significant clinical heterogeneity and dynamic natural course.
Ting-Rong Hsu, Pei-Hao Chen, Wei-Sheng Lin   +2 more
doaj   +1 more source