Results 81 to 90 of about 48,304 (243)

Utility and effectiveness of the Scandinavian guidelines to exclude computerized tomography scanning in mild traumatic brain injury - a prospective cohort study

BMC Emergency Medicine, 2018
Background In 2013 the Scandinavian Neurotrauma Committee (SNC) published updated guidelines for the initial management of minimal, mild and moderate traumatic head injuries (MTHI) that included serum analysis of protein S100B as a marker for brain ...
Arurann Ananthaharan, Gunnhild Kravdal, Truls Martin Straume-Naesheim   +2 more
doaj   +1 more source

S100B sebagai Prediktor Defisit Neurologi pada Anak dengan Sepsis

Sari Pediatri, 2020
Latar belakang. Respon sepsis merupakan rantai kejadian yang kompleks, terdiri dari proses inflamasi dan anti inflamasi, reaksi humoral dan selular, dan abnormalitas hemodinamik.
Jati Kusuma Wardhani, Tjipta Bahtera
doaj   +1 more source

Increased serum S100B in never-medicated and medicated schizophrenic patients

, 2010
S100B is a calcium-binding protein, which is produced primarily by glial cells. It modulates the proliferation and differentiation of neurons and glia by affecting protective and apoptotic mechanisms.
Kosten, Thomas R., Haile, Colin N., Chen, Da Chun, Zhang, Xiang Yang, Wu, Gui Ying, Kosten, Therese A., Xiu, Mei Hong, Song, Cai   +7 more
core   +1 more source

S100B Antibody Comparison.

, 2013
Twelve different types of human tissues were assessed for S100B expression by two different antibodies by Western blot. The OriGene monoclonal antibody was made by immunizing against a synthetic peptide corresponding to residues on the C-terminus of ...
Vincent Fazio (16280), Qingshan Teng (361887), Peter Biberthaler (361888), Damir Janigro (4975), Luca Cucullo (4970), Nancy Pham (361886), Jeffrey J. Bazarian (361889)   +6 more
core   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

Serum methylmalonic acid levels and epilepsy prevalence: Association analysis, exploratory mediation, and clinical corroboration

Epileptic Disorders, EarlyView.
Abstract Objective This study aimed to investigate the association between methylmalonic acid (MMA) and epilepsy prevalence and to explore potential inflammatory and nutritional pathways underlying this association. Methods This study included adults aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 2011–2014.
Ningyu Wei, Ning Huang, Haipeng Chen, Rui Tang, Yuan Cheng, Xiang Zhang   +5 more
wiley   +1 more source

A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children

Journal of Neuroinflammation, 2012
Background S100B is a calcium-binding protein that is produced primarily by astrocytes. Increased serum S100B protein levels reflect neurological damage. Autoimmunity may have a role in the pathogenesis of autism in some patients.
Al-Ayadhi Laila, Mostafa Gehan
doaj   +1 more source

The calcium binding S100B protein as a new modulator of amyloid-β peptide aggregation

, 2019
Amyloid aggregation and chronic neuroinflammation are pathological hallmarks in Alzheimer’s disease. Interestingly, important neuronal components such as pro-inflammatory cytokines and transition metal ion levels are also consistently deregulated in AD ...
Cristóvão, Joana Margarida Lopes da Silva
core