Results 41 to 50 of about 262,483 (141)

SADS-CoV triggers autophagy through activating ER stress.

, 2023
(A-C) SADS-CoV infection causes ER stress by activating all three UPR pathways in vitro. (A) Expansion of the ER is detected with transmission electron microscopy (TEM).
Jianfei Chen (3186999), Zhaoyang Jing (9110860), Haojie He (14761730), Hongyan Shi (1988656), Dakai Liu (10474934), Da Shi (1455439), Jingyun Ma (1885213), Tingshuai Feng (14761721), Li Feng (77923), Ling Zhou (51948), Jiyu Zhang (725001), Xin Zhang (35492), Mei Xue (163742), Jianbo Liu (315277), Jialin Zhang (320005), Zhaoyang Ji (14761727), Longjun Guo (315268), Liaoyuan Zhang (12157704), Miaomiao Zeng (14761724), Yang Wu (66682)   +19 more
core   +2 more sources

Cholesterol 25-Hydroxylase Suppresses Swine Acute Diarrhea Syndrome Coronavirus Infection by Blocking Spike Protein-Mediated Membrane Fusion

Viruses, 2023
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine intestinal coronavirus that can cause acute diarrhea, vomiting, rapid weight loss, and high mortality in newborn piglets.
Dakai Liu, Da Shi, Hongyan Shi, Liaoyuan Zhang, Jiyu Zhang, Miaomiao Zeng, Tingshuai Feng, Xiaoman Yang, Xin Zhang, Jianfei Chen, Zhaoyang Jing, Zhaoyang Ji, Jialin Zhang, Li Feng   +13 more
doaj   +1 more source

Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon-β Production via Blocking the Interaction Between TRAF3 and TBK1

Frontiers in Immunology, 2021
Swine acute diarrhea syndrome coronavirus (SADS-CoV), first discovered in 2017, is a porcine enteric coronavirus that can cause acute diarrhea syndrome (SADS) in piglets.
Zhihai Zhou, Zhihai Zhou, Yuan Sun, Yuan Sun, Jingya Xu, Jingya Xu, Xiaoyu Tang, Xiaoyu Tang, Ling Zhou, Ling Zhou, Qianniu Li, Qianniu Li, Tian Lan, Tian Lan, Jingyun Ma, Jingyun Ma   +15 more
doaj   +1 more source

A trimer ancestral spike-based mRNA vaccine confers cross-generational protection against SADS-CoV. [PDF]

J Nanobiotechnology
The emergence of coronavirus variants that evade vaccine protection poses a serious threat to both human health and animal husbandry, including the novel SADS-CoV, an emerging bat-derived coronavirus. Herein, we introduce a "phylogenetic antigen reconstruction" strategy to design a trimeric ancestral spike (tAS) antigen sequence based on evolutionary ...
Zhang T, Yao J, Guo X, Leng C, Liu S, Chen Y, Wang J, Sun M, Ma H, Li L, Yang K, Wang Y, Zhang G, Yao L.   +13 more
europepmc   +3 more sources

SADS-CoV infection induces autophagy in cultured cells.

, 2023
(A) Vero E6 cells are mock-infected or infected with SADS-CoV for 36 h, and then processed for an observation with transmission electron microscopy (TEM). Black arrows indicate characteristics of single- or double-membrane vesicles. Scale bars indicate 1
Jianfei Chen (3186999), Zhaoyang Jing (9110860), Haojie He (14761730), Hongyan Shi (1988656), Dakai Liu (10474934), Da Shi (1455439), Jingyun Ma (1885213), Tingshuai Feng (14761721), Li Feng (77923), Ling Zhou (51948), Jiyu Zhang (725001), Xin Zhang (35492), Mei Xue (163742), Jianbo Liu (315277), Jialin Zhang (320005), Zhaoyang Ji (14761727), Longjun Guo (315268), Liaoyuan Zhang (12157704), Miaomiao Zeng (14761724), Yang Wu (66682)   +19 more
core   +2 more sources

PF-00835231 broadly inhibits swine Alpha-coronavirus, including emerging SADS-CoV. [PDF]

J Virol
ABSTRACT Swine Alpha-coronaviruses are one of the most destructive pathogens affecting the swine industries across the world. Swine Alpha-coronaviruses include transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus, porcine respiratory coronavirus, and swine acute diarrhea syndrome
Shi L, Duan Y, Cao L, Zhang Y, Yuan C, Sun M, Zhang J, Kong X, Zheng H, Wang Q.   +9 more
europepmc   +3 more sources

SADS-CoV-induced complete autophagy is beneficial for viral replication.

, 2023
Vero E6 and ST cells are mock-pretreated or pretreated with complete medium containing 20 mM chloroquine (CQ) (A and E) or 20 nM BAF A1 (C and G) for 2 h and then subjected to SADS-CoV absorption for 1 h, and further cultured in fresh medium in the ...
Jianfei Chen (3186999), Zhaoyang Jing (9110860), Haojie He (14761730), Hongyan Shi (1988656), Dakai Liu (10474934), Da Shi (1455439), Jingyun Ma (1885213), Tingshuai Feng (14761721), Li Feng (77923), Ling Zhou (51948), Jiyu Zhang (725001), Xin Zhang (35492), Mei Xue (163742), Jianbo Liu (315277), Jialin Zhang (320005), Zhaoyang Ji (14761727), Longjun Guo (315268), Liaoyuan Zhang (12157704), Miaomiao Zeng (14761724), Yang Wu (66682)   +19 more
core   +2 more sources

SADS-CoV oral infection leads to a significant increase of bile acids in the small intestine of piglets.

, 2022
(A) Kinetic of viral shedding in fecal swabs from sucking piglets orally infected with SADS-CoV (n = 6). (B) Principal components analysis (PCA) of the duodenum and ileum from SADS-CoV-infected and mock-infected piglets.
Chan Ding (317445), Yao-Wei Huang (426136), Shu Jeffrey Zhu (12867687), Yi-Xin Tang (12867684), Pan Qin (6517490), Qi-Yue Yang (12867681), Shu-Xian Chen (10719084), Jin-Yan Xie (9920614), Yong-Le Yang (10977618), Gan Wang (786657)   +9 more
core   +2 more sources

Molecular characterization and evolutionary dynamics of a recombinant PDCoV strain in a swine diarrhea epidemic with SADS-CoV co-infection. [PDF]

Front Vet Sci
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that poses a significant threat to the swine industry. In this study, a novel PDCoV strain, designated PDCoV-ZJHZ2024, was identified from fecal samples of diarrheic pigs in China.
Cao HT, Sun RJ, Qian QY, Yang D, Sun YY, Zhao LY, Zhang GY, Zhang MD, Gu H, Cao HW, Wang B, Huang YW, Yang YL.   +12 more
europepmc   +4 more sources

Emodin from Aloe inhibits Swine acute diarrhea syndrome coronavirus in cell culture

Frontiers in Veterinary Science, 2022
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging swine enteropathogenic coronavirus that causes severe diarrhea in neonatal piglets, leading to serious economic losses to the pig industries.
Shumei Zheng, Xiaowei Wang, Huiqiong Hu, Yongbo Xia, Xiaoyuan Diao, Wenjing Qiu, Chunyi Xue, Yongchang Cao, Zhichao Xu   +8 more
doaj   +1 more source