Results 21 to 30 of about 262,483 (141)

Identification of a Receptor Tyrosine Kinase Inhibitor CP-724714 Inhibits SADS-CoV Related Swine Diarrhea Coronaviruses Infection in Vitro [PDF]

Virologica Sinica, 2023
The outbreak of the COVID-19 epidemic in 2020 has caused unprecedented panic among all mankind, pointing the major importance of effective treatment. Since the emergence of the swine acute diarrhea syndrome coronavirus (SADS-CoV) at the end of 2017, multiple reports have indicated that the bat-related SADS-CoV possesses a potential threat for cross ...
Jingyun Ma, Tian Lan
exaly   +4 more sources

Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection [PDF]

Proceedings of the National Academy of Sciences, 2022
Zoonotic transmission of coronaviruses poses an ongoing threat to human populations. Endemic outbreaks of swine acute diarrhea syndrome coronavirus (SADS-CoV) have caused severe economic losses in the pig industry and have the potential to cause human ...
Shaffer, Kendall M., Munt, Jennifer E., Adams, Lily E., Dong, Stephanie, Araba, Kenza C., Hou, Yixuan J., Morowitz, Jeremy M., Meganck, Rita M., Ehre, Camille, Wykoff, Jason A., Baric, Ralph S., Marzluff, William F., Tse, Longping V., Gonzalez, Liara M., Magness, Scott T., Yount, Boyd L., Kendall M. Shaffer, Stephanie Dong, Liara M. Gonzalez, Jeremy M. Morowitz, Longping V. Tse, Jennifer E. Munt, William F. Marzluff, Ralph S. Baric, Kenza C. Araba, Jason A. Wykoff, Camille Ehre, Lily E. Adams, Scott T. Magness, Yixuan J. Hou, Boyd L. Yount, Rita M. Meganck   +31 more
core   +3 more sources

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. [PDF]

Nat Commun, 2020
Several coronaviruses infecting humans and animals have emerged in recent years. Here, the authors provide structures of the spike proteins of the porcine coronavirus SADS-CoV and closely related bat coronavirus HKU2, providing insights into evolution of
Yu J, Qiao S, Guo R, Wang X.
europepmc   +8 more sources

NS7a Of SADS-CoV Promotes Viral Infection via Inducing Apoptosis to Suppress Type III Interferon Production [PDF]

Journal of Virology
ABSTRACT Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered swine coronavirus with potential cross-species transmission risk. Although SADS-CoV-induced host cell apoptosis and innate immunity antagonization has been revealed, underlying signaling pathways remain obscure.
Chunyi Xue, Zhichao Xu, Xiaoyuan Diao
exaly   +4 more sources

A Customized Novel Blocking ELISA for Detection of Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Infection

Microbiology Spectrum, 2023
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered emerging alphacoronavirus. SADS-CoV shares over 90% genome sequence identity with bat alphacoronavirus HKU2.
Liyan Cao, Xiangyu Kong, Xiangtong Li, Xuepeng Suo, Yueyue Duan, Cong Yuan, Yu Zhang, Haixue Zheng, Qi Wang   +8 more
doaj   +2 more sources

Establishment of a Novel Double-Antibody Sandwich Fluorescence Microsphere Immunochromatographic Test Strip for Rapid Detection of Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) Infection [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionSwine acute diarrhea syndrome coronavirus (SADS-CoV) is an enveloped, positive-sense, single-stranded RNA virus that causes clinical symptoms such as vomiting and diarrhea in 10-day-old piglets. SADS-CoV has caused significant economic losses
Xiao Cong, Yujun Zhu
exaly   +4 more sources

Autophagy is induced by swine acute diarrhea syndrome coronavirus through the cellular IRE1-JNK-Beclin 1 signaling pathway after an interaction of viral membrane-associated papain-like protease and GRP78.

PLoS Pathogens, 2023
Autophagy plays an important role in the infectious processes of diverse pathogens. For instance, cellular autophagy could be harnessed by viruses to facilitate replication.
Da Shi, Ling Zhou, Hongyan Shi, Jiyu Zhang, Jialin Zhang, Liaoyuan Zhang, Dakai Liu, Tingshuai Feng, Miaomiao Zeng, Jianfei Chen, Xin Zhang, Mei Xue, Zhaoyang Jing, Jianbo Liu, Zhaoyang Ji, Haojie He, Longjun Guo, Yang Wu, Jingyun Ma, Li Feng   +19 more
doaj   +2 more sources

Development of a TaqMan-Based Real-Time RT-PCR Assay for the Detection of SADS-CoV Associated With Severe Diarrhea Disease in Pigs [PDF]

Journal of Virological Methods, 2018
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel coronavirus which was first reported in southern China in 2017. It can cause severe diarrhea disease in pigs. In order to detect this new emerging virus rapidly and reliably, a TaqMan-based real-time RT-PCR assay was established in this study.
Kai-Jie Mai
exaly   +4 more sources

Unraveling the Assembly Mechanism of SADS-CoV Virus Nucleocapsid Protein: Insights From RNA Binding, Dimerization, and Epitope Diversity Profiling [PDF]

Journal of Virology
ABSTRACT The swine acute diarrhea syndrome coronavirus (SADS-CoV) has caused significant disruptions in porcine breeding and raised concerns about potential human infection. The nucleocapsid (N) protein of SADS-CoV plays a vital role in viral assembly and replication, but its structure and functions remain poorly ...
Wei Xu, Xiwen Jiang, Yuzhe Wu
exaly   +4 more sources

Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) Antagonizes Interferon-β Production via Blocking IPS-1 and RIG-I [PDF]

Virus Research, 2020
Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. Interactions between SADS-CoV and the host innate immune response is unclear yet.
Tian Lan, Xiaoyu Tang
exaly   +4 more sources