Identification of TMEM53 as a Novel SADS-CoV Restriction Factor That Targets Viral RNA-Dependent RNA Polymerase [PDF]
Emerging Microbes and Infections, 2023 Zoonotic transmission of coronaviruses (CoVs) poses a serious public health threat. Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to ...
Geng Rong, Mei-Qin Liu, Yu-Lin Yao
exaly +8 more sources
SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε [PDF]
MicroorganismsSwine acute diarrhea syndrome coronavirus (SADS-CoV), initially identified in China in February 2017, severely impacts the swine industry by causing lethal watery diarrhea in neonatal piglets. Understanding the molecular mechanism employed by SADS-CoV to
Yongchang Cao
exaly +7 more sources
Swine Acute Diarrhoea Syndrome Coronavirus (SADS-CoV) Nsp5 Antagonizes Type I Interferon Signaling by Cleaving DCP1A [PDF]
Frontiers in Immunology, 2023 Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which is a recently discovered enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and intestinal pathological damage in pigs, and it has caused significant ...
Hui-Jun Lu, Xiao-Xiao Lei, Bao-Peng Zhao
exaly +8 more sources
PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy [PDF]
Veterinary SciencesSwine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel enteric coronavirus that causes severe clinical diarrhea and intestinal pathological injury in pigs.
Wenchao Sun, Haixin Huang, Chenchen Zhao
exaly +7 more sources
Crystal Structures of Fusion Cores From CCoV-HuPn-2018 and SADS-CoV [PDF]
VirusesCross-species spillover to humans of coronaviruses (CoVs) from wildlife animal reservoirs poses marked and global threats to human and animal health. Recently, sporadic infection of canine coronavirus–human pneumonia-2018 (CCoV-HuPn-2018) in hospitalized
Lei Yan
exaly +7 more sources
Update on the Phylodynamics of SADS-CoV [PDF]
Life, 2021 Coronaviruses are known to be harmful and heterogeneous viruses, able to infect a large number of hosts. Among them, SADS-CoV (Swine Acute Diarrhea Syndrome Coronavirus), also known as PEAV (Porcine Enteric Alphacoronavirus), or SeA-CoV (Swine Enteric ...
Fabio Scarpa +10 more
doaj +11 more sources
SADS-CoV NS3 induces apoptosis by blocking the formation of Bcl-xL-BAK complex [PDF]
Journal of VirologySwine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine coronavirus with characteristics of bat origin, posing a potential threat to animal welfare and public health.
Chunxiao Mou +8 more
doaj +4 more sources
An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases. [PDF]
PLoS PathogensSwine acute diarrhea syndrome coronavirus (SADS-CoV) poses a significant zoonotic risk. The absence of the structure of SADS-CoV main protease (Mpro) severely impedes the development of effective antiviral therapeutics.
Rui Zeng +11 more
doaj +4 more sources
MOV10 inhibits SADS-CoV replication by enhancing TRIM24-mediated K63-linked TRAF3 ubiquitination, and this inhibition is antagonized by viral N protein [PDF]
Journal of VirologyThe global outbreak of SARS-CoV-2 has resulted in a renewed focus on coronaviruses with the potential for cross-species transmission and mutation risks. In particular, swine acute diarrhea syndrome coronavirus (SADS-CoV), potentially originating from the
Miaomiao Zeng +14 more
doaj +3 more sources
PABPC1 Restricts Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Infection via TOLLIP-Mediated Degradation of Viral Nucleocapsid Protein [PDF]
PathogensThe emergence of swine acute diarrhea syndrome coronavirus (SADS-CoV), an alpha-coronavirus that causes fatal enteric disease in neonatal piglets with mortality rates up to 90%, demonstrates that bat-origin coronavirus has expanded its host range to pigs.
Maowen Sun +9 more
doaj +3 more sources