Results 11 to 20 of about 262,483 (141)

Combined Analysis of the Whole Transcriptome of Piglets Infected With SADS−CoV Virulent and Avirulent Strains [PDF]

Microorganisms, 2023
When piglets are infected by virulent and avirulent strains of swine acute diarrhea syndrome coronavirus (SADS−CoV), there are obvious differences in their clinical symptoms; however, the specific mechanisms of pathogenicity and the immune ...
Tian Lan, Xiaoyu Tang
exaly   +6 more sources

Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development [PDF]

Frontiers in Immunology
IntroductionSwine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine enteric coronavirus that can cause diarrhea in piglets younger than 5 days of age.
Xiaoling Yan, Xiaoli Zhang, Xiaocheng Lyu, Xiaocheng Lyu, Yaoyao Zheng, Yaoyao Zheng, Qianniu Li, Qianniu Li, Xiaoya Zhao, Jun Fu, Jingyun Ma   +10 more
doaj   +5 more sources

Effects of SADS‐CoV accessory proteins NS3a, NS7a, and NS7b on viral pathogenicity: A multi‐omics investigation [PDF]

iMetaOmics
Swine acute diarrhea syndrome coronavirus (SADS‐CoV) is an emerging, novel porcine coronavirus that causes acute diarrhea and vomiting in piglets, leading to significant neonatal morbidity and a mortality rate exceeding 90%.
Xiaoling Yan, Xiaoli Zhang, Ling Zhou, Xiaoya Zhao, Qianniu Li, Tian Lan, Jun Fu, Jingyun Ma   +7 more
doaj   +4 more sources

Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection [PDF]

mBio
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging bat-origin alphacoronavirus causing severe disease in neonatal piglets, with significant economic losses to the swine industry.
Hanyu Zhang, Mengdi Zhang, Jiaru Zhou, Pengfei Li, Ran Jing, Hongmei Zhu, Yifei Lang, Qigai He, Mengjia Zhang, Wentao Li   +9 more
doaj   +4 more sources

Rab10 coordinates SADS-CoV non-lytic egress through the ERGIC-TGN-lysosome trafficking pathway. [PDF]

PLoS Pathogens
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a bat-originated alphacoronavirus that causes devastating enteric disease in neonatal piglets and possesses significant potential for cross-species transmission.
Liaoyuan Zhang, Jiyu Zhang, Mei Xue, Mengyu Liu, Xinwei Sun, Dakai Liu, Miaomiao Zeng, Gengting Gu, Hongyan Shi, Xin Zhang, Jianfei Chen, Zhaoyang Ji, Da Shi, Li Feng   +13 more
doaj   +4 more sources

Development of a Novel Double-Antibody Sandwich Quantitative ELISA for Detecting SADS-CoV Infection [PDF]

Applied Microbiology and Biotechnology, 2023
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging swine enteric alphacoronavirus that can cause acute diarrhea, vomiting, dehydration, and death of newborn piglets. In this study, we developed a double-antibody sandwich quantitative enzyme-linked immunosorbent assay (DAS-qELISA) for detection of SADS-CoV by using an anti-SADS-CoV N ...
Qi Wang, Cong Yuan, Yueyue Duan
exaly   +4 more sources

The Re-Emerging of SADS-CoV Infection in Pig Herds in Southern China [PDF]

Transboundary and Emerging Diseases, 2019
A new highly virulent swine acute diarrhoea syndrome coronavirus (SADS-CoV) emerged in Guangdong province in 2017 followed by fatal diarrhoea that involved the death of 24,693 piglets. And yet from May 2017 to January 2019, there were no new SADS cases arising in pig herds in Guangdong.
Zhou L, Li QN, Su JN, Chen GH, Wu ZX, Luo Y, Wu RT, Sun Y, Lan T, Ma JY.   +9 more
exaly   +5 more sources

Structural and Biochemical Characterization of SADS-CoV Papain-Like Protease 2 [PDF]

Protein Science, 2020
AbstractSwine acute diarrhea syndrome coronavirus (SADS‐CoV) is a novel coronavirus that is involved in severe diarrhea disease in piglets, causing considerable agricultural and economic loss in China. The emergence of this new coronavirus increases the importance of understanding SADS‐CoV as well as antivirals.
Chengpeng Fan, Weihua Hu
exaly   +5 more sources

Establishment of Replication-Competent Vesicular Stomatitis Virus Recapitulating SADS-CoV Entry [PDF]

Journal of Virology
ABSTRACT Zoonotic coronaviruses pose a continuous threat to human health, with newly identified bat-borne viruses like swine acute diarrhea syndrome coronavirus (SADS-CoV) causing high mortality in piglets.
Qiang Ding, Rong Zhang, Mingli Gong
exaly   +4 more sources

Epitopes screening and vaccine molecular design of SADS-CoV based on immunoinformatics. [PDF]

Front Vet Sci, 2022
The regional outbreak of the Swine acute diarrhea syndrome coronavirus (SADS-CoV) has seriously threatened the swine industry. There is an urgent need to discover safe and effective vaccines to contain them quickly. The coronavirus spike protein mediates
Li S, Chen Y.
europepmc   +5 more sources