Results 71 to 80 of about 7,778,220 (309)
, 2003 Four community-based pilot projects for leveraging public-private partnerships to expand health care coverage among low-wage ...
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
EFSA Journal, 2012 In this report, harmonised epidemiological indicators are proposed for food‐borne biological hazards to public health that are related to poultry and meat thereof and that can be addressed within meat inspection.
European Food Safety Authority
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
EFSA Journal, 2012 Proposals to improve the harmonisation of monitoring and reporting of antimicrobial resistance in Salmonella, Campylobacter coli and jejuni, indicator Escherichia coli and Enterococcus from food producing animals and derived meat by the European Union ...
European Food Safety Authority
doaj +1 more source
Situational analysis on safety and health in primary school in Kota Bharu [PDF]
, 2009 Background : Safety and health is one of major concerns in public health issues. There are lots of injuries or accidents reported in the news which include school accidents and injuries.
Nurul AH,, Tengku MA,
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Understanding the role of local safety groups in managing safety practices between micro construction firms and principal contractors [PDF]
, 2014 Construction projects incorporate the input of a range of tradesmen and different sized firms, ranging from micro to large organisations. Working practices of micro construction firms are carried out in an informal manner while larger organisations tend ...
Aboagye-Nimo, E, King, A, Raidén, A
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source