The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Reasoned opinion on the modification of the existing MRL for folpet in wine grapes
EFSA Journal, 2012 In accordance with Article 6 of Regulation (EC) No 396/2005, Austria, herewith referred as the evaluating Member State (EMS), received an application from Makhteshim Agan to modify the existing MRL for folpet in wine grapes.
European Food Safety Authority
doaj +1 more source
Efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies: a randomized, double‐blind, placebo‐controlled study [PDF]
, 2003 Michael Hedenus +13 more
openalex +1 more source
Pesticides, environment, and food safety
, 2017 Agrochemicals have enabled to more than duplicate food production during the last century, and the current need to increase food production to feed a rapid growing human population maintains pressure on the intensive use of pesticides and fertilizers ...
F. Carvalho
semanticscholar +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Holding GLP-1 Agonists Prior to Elective Procedures
Patient Safety, 2023 Patient Safety Authority
doaj +1 more source
Reasoned opinion on the modification of the existing MRLs for ametoctradin in various commodities
EFSA Journal, 2012 In accordance with Article 6 of Regulation (EC) No 396/2005, The Netherlands, hereafter referred to as the evaluating Member State (EMS), received an application from the company BASF SE to modify the existing MRL for the active substance ametoctradin in
European Food Safety Authority
doaj +1 more source
Safety and Efficacy of Adalimumab for Moderate to Severe Crohn's Disease in Children [PDF]
, 2012 Jeffrey S. Hyams +13 more
openalex +1 more source
Challenges in the Safety-Security Co-Assurance of Collaborative Industrial Robots [PDF]
, 2021 Mario Gleirscher +5 more
openalex +1 more source
Artificial intelligence, bias and clinical safety
BMJ Quality & Safety, 2019 In medicine, artificial intelligence (AI) research is becoming increasingly focused on applying machine learning (ML) techniques to complex problems, and so allowing computers to make predictions from large amounts of patient data, by learning their own ...
R. Challen +5 more
semanticscholar +1 more source