Results 61 to 70 of about 947,047 (350)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes

The Plant Genome
Salinity is a major abiotic stress factor that can significantly impact crop growth, and productivity. In response to salt stress, the plant Salt Overly Sensitive (SOS) signaling pathway regulates the homeostasis of intracellular sodium ion concentration.
Biswa R. Acharya, Chaoyang Zhao, Lorenso Antonio Rodriguez Reyes, Jorge F. S. Ferreira, Devinder Sandhu   +4 more
doaj   +1 more source

Seed priming with titanium dioxide nanoparticles enhances seed vigor, leaf water status, and antioxidant enzyme activities in maize (Zea mays L.) under salinity stress

, 2021
Objectives Current study illustrates the impact assessment of TiO2 nano-particle seed priming on the overall germination, physiology in maize thriving under salinity stress.
T. Shah, Sadia Latif, Fozia Saeed, Izhar Ali, Saif Ullah, Abdulaziz Abdullah Alsahli, Sumira Jan, P. Ahmad   +7 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Phosphorus-solubilizing fungi improve growth and P nutrition in sorghum at variable salinity levels

Environmental Microbiome
Background Salt–tolerant phosphorus solubilizing fungi (PSF) play a pivotal role in plant growth promotion and P–nutrition in saline agro–ecoregions. Isolation and characterization of salt–tolerant fungi with P-solubilizing potential and plant growth ...
Priyanka Chandra, Arvind Kumar Rai, Nirmalendu Basak, Parul Sundha, Kailash Prajapat, Awtar Singh, Anita Mann, R. K. Yadav   +7 more
doaj   +1 more source

Assessing long term impact of nutrient management and rainfall variability on the agroecological resilience of maize (Zea mays)- wheat (Triticum aestivum) system in NW India

The Indian Journal of Agricultural Sciences, 2016
A long-term (2000-2010) field experiment was carried out in the lower Shiwalik foothills of Punjab to study the carry over effect of organic manures and fertilizers on the productivity of maize (Zea mays L.)- wheat (Triticum aestivum L.) cropping system
P SHEORAN, SHER SINGH, S S BAWA, V SARDANA, ASHWANI KUMAR, RAJKUMAR, B BHUSHAN, G S DHERI   +7 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Temporal variations in morpho-physiology of sandalwood and gene expression analysis revealed Shisham as host preference under water deficit and salinity stress

BMC Plant Biology
Background Sandalwood (Santalum album L.), a valuable aromatic tree species, faces significant growth and physiological challenges under abiotic stresses like water deficit and salinity, especially when both stressors are present. Host plant associations
Ashwani Kumar, Aarju Sharma, Shruti Kaushik, Antim Kundu, Pooja Dhansu, Kamlesh Verma, Raj Kumar, Abdulaziz Abdullah Alsahli, Parvender Sheoran   +8 more
doaj   +1 more source

A multi-dimensional analysis of integrated farming system in salt-affected ecologies

The Indian Journal of Agricultural Sciences
The horizontal expansion of the arable areas seems infeasible with dwindling natural resources and declining the average size of landholdings. For harnessing the economic, environmental and social benefits of vertical expansion, the Integrated Farming ...
RAJKUMAR, SURESH KUMAR, RAM KISHOR FAGODIYA, AWTAR SINGH, PARVENDER SHEORAN, GAJENDER YADAV, NIRMAL SINGH, SUBHASIS MANDAL, R K YADAV   +8 more
doaj   +1 more source

Salinity and drought induced changes in gas exchange attributes and chlorophyll fluorescence characteristics of rice (Oryza sativa) varieties

The Indian Journal of Agricultural Sciences, 2016
The present study was conducted to assess the effect of water deficit coupled with salt stress on physiological traits and stress tolerance mechanisms of rice (Oryza sativa L.) varieties differing in salt tolerance.
ASHWANI KUMAR, CHARU LATA, PARVEEN KUMAR, RITU DEVI, KAILASH SINGH, S L KRISHNAMURTHY, NEERAJ KULSHRESHTHA, RAJENDER K YADAV, SURINDER K SHARMA   +8 more
doaj   +1 more source