Results 191 to 200 of about 7,383 (256)

Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells.

Colloids and Surfaces B: Biointerfaces, 2021
Cancer stem cells (CSCs) comprise a diminutive population of the tumor but pose major obstacles in cancer treatment, often their presence being correlated with poor prognosis, therapeutic resistance and relapse.
Suparna Mercy Basu, S. Yadava, Ruby Singh, Jyotsnendu Giri   +3 more
semanticscholar   +1 more source

Salinomycin toxicosis in horses

Journal of the American Veterinary Medical Association, 2007
Abstract Case Description—A 4-month-old American Paint filly was evaluated because of sudden onset of ataxia that progressed to recumbency. Five additional horses from the same and neighboring premises developed signs of poor performance, generalized weakness, ataxia, and recumbency; 2 of those horses were also evaluated.
Monica, Aleman, K Gary, Magdesian, Tracy S, Peterson, Francis D, Galey   +3 more
openaire   +2 more sources

Salinomycin-loaded Injectable Thermosensitive Hydrogels for Glioblastoma Therapy.

International journal of pharmaceutics, 2021
Local drug delivery approaches for treating brain tumors not only diminish the toxicity of systemic chemotherapy, but also circumvent the blood-brain barrier (BBB) which restricts the passage of most chemotherapeutics to the brain.
M. Norouzi, J. Firouzi, N. Sodeifi, Marzieh Ebrahimi, Donald W. Miller   +4 more
semanticscholar   +1 more source

Salinomycin alleviates osteoarthritis progression via inhibiting Wnt/β-catenin signaling.

International Immunopharmacology, 2022
Osteoarthritis (OA) is the most prevalent degenerative whole-joint disease characterized by cartilage degeneration, synovial hyperplasia, osteophyte formation, and subchondral bone sclerosis.
Jing Chen, Jia Liu, Shimin Chen, Rui Lai, Chuanchuan Zheng, Jiaping Lu, Xinshao Jiang, Feng He, Cheng-liang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang   +12 more
semanticscholar   +1 more source

Green one-pot synthesis of nitrogen and sulfur co-doped carbon quantum dots as new fluorescent nanosensors for determination of salinomycin and maduramicin in food samples.

Food Chemistry, 2020
A simple green hydrothermal method was proposed for synthesis of highly fluorescent nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) using citric acid and thiosemicarbazide.
Galal Magdy, A. F. Abdel Hakiem, F. Belal, A. Abdel-Megied   +3 more
semanticscholar   +1 more source

Synthesis of salinomycin

Journal of the Chemical Society, Perkin Transactions 1, 1998
Salinomycin, a commercially significant coccidiostat isolated from Streptomyces albus, has been synthesised from three principal fragments. Key steps include (a) the use of η3-allylmolybdenum cationic complexes 21a,b for the stereoselective construction of two contiguous stereogenic centres in fragment 5a; (b) the electrophilic cyclisation of 2-(prop-2-
Philip J. Kocieński, Richard C. D. Brown, Agnès Pommier, Martin Procter, Bernd Schmidt   +4 more
openaire   +1 more source

Production of Monoclonal Antibodies to Salinomycin

Hybridoma, 1986
Protein conjugates of salinomycin were prepared and utilized to produce murine monoclonal antibodies (MAbs) in the BALB/c-P3X63.Ag 8.653 fusion system. Several antibodies were cloned, stabilized, and evaluated for cross-reactivity to other ionophorous antibiotics.
G A, Miller, R C, Clark, E J, Jessee
openaire   +2 more sources

Positive regulation of MarR-type regulator slnO and improving salinomycin production of Streptomyces albus by multiple transcriptional regulations.

Canadian Journal of Microbiology (print), 2022
The purpose of this study is to explore the function of MarR-family regulator slnO. In addition, the high-yield strain of salinomycin was constructed by using combined regulation strategies.
Hongrui Zhang, Weiwei Chen, Xinyi Wang, Yongquan Li, Zhenhong Zhu   +4 more
semanticscholar   +1 more source

Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives.

Organic and biomolecular chemistry, 2022
Seventeen C20-O-alkyl/benzyl oxime derivatives were synthesized by a concise and effective method. Most of these derivatives showed tens to several hundred nanomolar IC50 values against HT-29 colorectal, HGC-27 gastric and MDA-MB-231 breast cancer cells,
Bo Li, Jun Wu, Lei Tang, Xu Lian, Zhongwen Li, Wenfang Duan, Tong Qin, Xintong Zhao, Yuhua Hu, Chi Zhang, Tianlei Li, Jie Hao, Wenxuan Zhang, Jihong Zhang, Song Wu   +14 more
semanticscholar   +1 more source

Salinomycin inhibits SREBP1 to sensitize ferroptosis and ameliorate sorafenib resistance in clear cell renal cell carcinoma.

Biochimica et biophysica acta. Molecular cell research
Backgrounds Resistance to sorafenib, a frontline therapy for advanced ccRCC, is associated with decreased sensitivity to ferroptosis. Our research focuses on elucidating the mechanisms underlying ccRCC's resistance to sorafenib-induced ferroptosis and ...
Yu Su, Xuan Liu, Dekun Wang, Gang Li, Xue Mi, Yuying Zhang, Shijing Yue, Zhujun Zhang, Tianyu Shen, Xiaoyue Tan   +9 more
semanticscholar   +1 more source