Results 201 to 210 of about 7,383 (256)

Effects of encapsulated butyrate and salinomycin on gut leakage and intestinal inflammation in broilers

British Poultry Science, 2022
1. The objectives of this study were to i) compare the effects of a commercial product providing encapsulated butyrate (EB) in combination with salinomycin in diets of broilers with impaired intestinal integrity and ii) to identify easy-to-measure ...
M. Naghizadeh, T. S. Dalgaard, Laura Klaver, R. Engberg   +3 more
semanticscholar   +1 more source

Reductive stress and cytotoxicity in the swollen river mussel (Unio tumidus) exposed to microplastics and salinomycin.

Environmental Pollution
Multistress effects lead to unpredicted consequences in aquatic ecotoxicology and are extremely concerning. The goal of this study was to trace how specific effects of the antibiotic salinomycin (Sal) and microplastics (MP) on the bivalve molluscs are ...
V. Martyniuk, Tetiana Matskiv, K. Yunko, V. Khoma, L. Gnatyshyna, C. Faggio, O. Stoliar   +6 more
semanticscholar   +1 more source

Stereoselective Synthesis of the Western Hemisphere of Salinomycin

Organic Letters, 2006
[structure: see text]. A convergent and module-based strategy for the asymmetric synthesis of the western hemisphere (C1-C17 fragment) of salinomycin has been devised. This new synthetic approach relies on highly stereoselective C-glycosidation and aldol processes.
Larrosa, I, Romea, P, Urpi, F
openaire   +4 more sources

CHEMISTRY AND BIOLOGY OF SALINOMYCIN AND ITS ANALOGUES

Targets in Heterocyclic Systems, 2015
Natural carboxylic polyether ionophores such as salinomycin, monensin, and lasalocid have been objects of great interest because of their antibacterial, antifungal, antiparasitic, and antiviral activities. Recently, it has been found that polyether ionophores might be also important chemotherapeutic agents in the treatment of cancer.
Piperno Anna, Marrazzo Agostino, Scala Angela, Rescifina Antonio   +3 more
openaire   +1 more source

Synergistic Effect of Salinomycin With Budesonide on TNBC Regression via EMT Reversal and Autophagy Induction

Journal of biochemical and molecular toxicology
Triple‐negative breast cancer (TNBC) poses a significant clinical challenge due to its aggressive nature, lack of specific therapeutic targets, and drug resistance.
Shilpi Sarkar, S. Ghosh
semanticscholar   +1 more source

Chemical biology of salinomycin

Tetrahedron, 2018
Abstract Cancer stem cells (CSC) have been shown to be refractory to conventional therapeutic agents, can promote metastasis, and have been linked to cancer relapse. The natural product Salinomycin has been identified by means of high throughput phenotypic screening as a selective killer of CSC in vitro and in vivo. In this article we comprehensively
Versini, Antoine, Saier, Lou, Sindikubwabo, Fabien, Müller, Sebastian, Cañeque, Tatiana, Rodriguez, Raphaël   +5 more
openaire   +2 more sources

Effective Synthesis of C20-epi-Isothiocyanato-Salinomycin and Its Thiourea Derivatives as Potential Anticancer Agents.

Chemistry
Salinomycin, a naturally occurring polyether ionophore antibiotic isolated from Streptomyces albus, has been demonstrated potent cytotoxic activity against a variety of cancer cell lines.
Rui Jiang, Xin Zhang, Na Li, Yuyin Mao, Huangli Chen, Zhouming Deng, Wentao Wang, Zhong-Xing Jiang, Liying Xu, Zhigang Yang   +9 more
semanticscholar   +1 more source

Salinomycin Toxicosis in Male Breeder Turkeys

Avian Diseases, 1995
A sudden outbreak of mortality in one house of 600 48-week-old male breeder turkeys on a five-house turkey breeder farm was suspected to be feed-related. The turkeys gasped and became recumbent; 21.7% of affected turkeys died. No significant gross lesions were found at necropsy.
J R, Andreasen, J H, Schleifer
openaire   +2 more sources

Salinomycin-Loaded Gold Nanoparticles for Treating Cancer Stem Cells by Ferroptosis-Induced Cell Death.

Molecular Pharmaceutics, 2019
Cancer stem cells (CSCs) are a subpopulation of tumor cells that exhibit self-renewal, differentiation, and tumorigenicity. CSCs are highly resistant to the conventional cancer treatment and have been associated with metastasis. Several studies have been
Yongmei Zhao, Wei Zhao, Y. Lim, Tianqing Liu   +3 more
semanticscholar   +1 more source

Antiproliferative activity of salinomycin and its derivatives

Bioorganic & Medicinal Chemistry Letters, 2012
Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines.
Adam, Huczyński, Jan, Janczak, Michał, Antoszczak, Joanna, Wietrzyk, Ewa, Maj, Bogumil, Brzezinski   +5 more
openaire   +2 more sources