Results 61 to 70 of about 36,795 (182)

Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents

Molecules, 2018
The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A), a
Bronwyn M. Kivell, Kelly F. Paton, Nitin Kumar, Aashish S. Morani, Aimee Culverhouse, Amy Shepherd, Susan A. Welsh, Andrew Biggerstaff, Rachel S. Crowley, Thomas E. Prisinzano   +9 more
doaj   +1 more source

Salvia Divinorum Use among a College Student Sample [PDF]

Journal of Drug Education, 2008
The recreational use of Salvia divinorum has received increased attention by media outlets and policy-makers in recent years. The vast absence of research to guide the dissemination of information has prompted this research note describing the use of this substance in a large public institution of higher education. The prevalence of Salvia divinorum is
David N, Khey, Bryan Lee, Miller, O Hayden, Griffin   +2 more
openaire   +2 more sources

CYP76BK1 orthologs catalyze furan and lactone ring formation in clerodane diterpenoids across the mint family

The Plant Journal, Volume 120, Issue 3, Page 984-997, November 2024.
SUMMARY The Lamiaceae (mint family) is the largest known source of furanoclerodanes, a subset of clerodane diterpenoids with broad bioactivities including insect antifeedant properties. The Ajugoideae subfamily, in particular, accumulates significant numbers of structurally related furanoclerodanes.
Nicholas J. Schlecht, Emily R. Lanier, Trine B. Andersen, Julia Brose, Daniel Holmes, Björn R. Hamberger   +5 more
wiley   +1 more source

Chinese Medicines and Natural Medicine as Immunotherapeutic Agents for Gastric Cancer: Recent Advances

Cancer Reports, Volume 7, Issue 9, September 2024.
ABSTRACT Backgroud According to the 2020 statistics from the World Health Organization’s International Agency for Research on Cancer (IARC), it is projected that there will be over 1 million new cases of gastric cancer (GC) patients worldwide in 2020, resulting in approximately 770 000 deaths.
Zhipeng Zhang, Ziqi Chen, Zujun Que, Zhihong Fang, Huirong Zhu, Jianhui Tian   +5 more
wiley   +1 more source

The Association of Salvia divinorum and Psychotic Disorders: A Review of the Literature and Case Series [PDF]

, 2015
The association of substance abuse and psychotic disorders is of interest to clinicians, academics, and lawmakers. Commonly abused substances, such as cannabis, cocaine, amphetamines, and alcohol, have all been associated with substance-induced psychosis.
El-Khoury, Joseph R., Sahakian, Nayiri
core   +1 more source

Chemical analysis of substitute drugs of abuse – “legal highs” from Lubuskie province, Poland

Journal of Medical Science, 2014
Introduction. Interest in substitute drugs of abuse, commonly called “dopalacze” [literally “after-burns”] that is “legal highs”, in Poland and abuse of such products, which could pose a significant life hazard, led to legislative action taken by the ...
Kinga Mruczyk, Krzysztof Durkalec-Michalski, Jan Jeszka, Joanna Lipińska, Zbigniew Stefański   +4 more
doaj   +1 more source

Different self‐damaging behaviours, similar motives? Testing measurement invariance of motives for nonsuicidal self‐injury, disordered eating and substance misuse

British Journal of Clinical Psychology, Volume 63, Issue 3, Page 394-415, September 2024.
Abstract Objectives Theory and research suggest that distinct self‐damaging behaviours (SDBs; e.g., nonsuicidal self‐injury [NSSI], restrictive eating, binge eating, drug misuse, alcohol misuse) share similar motives. However, few studies have used a common self‐report inventory to investigate the shared relevance and relative salience of motives for ...
Christina L. Robillard, Gabriel J. Merrin, Nicole K. Legg, Megan E. Ames, Brianna J. Turner   +4 more
wiley   +1 more source

Salvinorins J from Salvia divinorum: Mutarotation in the Neoclerodane System

, 2016
A search for biosynthetic precursors of salvinorin A (1) led to the isolation of a new neoclerodane diterpenoid hemiacetal mixture, salvinorins J (2), from the chloroform extract of Salvia divinorum.
Lukasz M. Kutrzeba (2303722), Daneel Ferreira (1320120), Jordan K. Zjawiony (374749)   +2 more
core   +1 more source

Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection

Molecular Pain, 2012
Background Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and
Guida Francesca, Luongo Livio, Aviello Gabriella, Palazzo Enza, De Chiaro Maria, Gatta Luisa, Boccella Serena, Marabese Ida, Zjawiony Jordan K, Capasso Raffaele, Izzo Angelo A, de Novellis Vito, Maione Sabatino   +12 more
doaj   +1 more source

Identification of clerodane diterpene modifying cytochrome P450 (CYP728D26) in Salvia divinorum ‐ en route to psychotropic salvinorin A biosynthesis

Physiologia Plantarum, Volume 176, Issue 5, September/October 2024.
Abstract Salvia divinorum is a hallucinogenic plant native to the Oaxaca in Mexico. The active ingredient for psychotropic effects in this plant is salvinorin A, a potent and highly selective κ‐opioid receptor agonist. Salvinorin A is distinct from other well‐known opioids, such as morphine and codeine, in that it is a non‐nitrogenous diterpenoid with ...
Iris Ngo, Rahul Kumar, Liang Li, Seon‐Won Kim, Moonhyuk Kwon, Dae‐Kyun Ro   +5 more
wiley   +1 more source