Opioid Receptors in Psychedelia: Indirect Serotonergic Modulation of Direct KOR Activation by Salvinorin A [PDF]
BiomedicinesThe neuropharmacology of psychedelics has traditionally focused on serotonergic mechanisms, particularly 5-HT2A receptor activation. However, this paradigm incompletely explains the diversity of neurobiological and therapeutic effects observed across ...
Maximiliano Ganado +6 more
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Comparative genome analysis provides a foundation for defining salvinorin A biosynthesis in Salvia divinorum [PDF]
Nature CommunicationsThe synthesis of salvinorin A by Salvia divinorum is of considerable interest for developing pain relief, anti-opioid addiction and antidepressant medications, but progress has been compromised by limited access to plant material and the complexity of ...
Haixiu Li +8 more
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The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies [PDF]
Translational PsychiatryBackground Salvinorin A, the main psychoactive compound of Salvia divinorum, is a potent and selective kappa opioid receptor agonist. While human clinical trials remain limited, animal studies suggest potential therapeutic applications in neurological ...
Wolfgang Emanuel Zürrer +4 more
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Structural characterization of kappa-opioid receptor dimer in complex with two G proteins [PDF]
Nature CommunicationsThe κ-opioid receptor (κOR) represents a promising non-addictive analgesic target due to its critical role in pain and reward pathways. Despite evidence of κOR dimerization, its molecular basis and pharmacological significance remain elusive.
Yuxi Zhao +15 more
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Emerging Psychotropic Drug for the Treatment of Trigeminal Pain: Salvinorin A [PDF]
PharmaceuticalsTrigeminal neuralgia (TN) is chronic pain caused by damage to the somatosensorial system on the trigeminal nerve or its branches, which involves peripheral and central dysfunction pain pathways.
Geovanna Nallely Quiñonez-Bastidas +3 more
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The influence of cultivation conditions on the formation of psychoactive salvinorin A, salvinorin B, rosmarinic acid and caffeic acid in Coleus scutellarioides [PDF]
Scientific ReportsColeus scutellarioides (L.) Benth. is a popular species in the world, known for its characteristic magnificent colourful leaves. The study has revealed that the contents of rosmarinic acid and caffeic acid are significantly higher in the plant tissues ...
Maciej Jakobina +3 more
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A chromosome level reference genome of Diviner’s sage (Salvia divinorum) provides insight into salvinorin A biosynthesis [PDF]
BMC Plant BiologyBackground Diviner’s sage (Salvia divinorum; Lamiaceae) is the source of the powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of the human Κ-opioid receptor with potential medical applications in the treatment of ...
Scott A. Ford +4 more
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Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community [PDF]
Harm Reduction JournalBackground The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This
Daniel J. Kruger +7 more
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Pharmaceuticals, 2021 Salvia divinorum Epling and Játiva is a perennial mint from the Lamiaceae family, endemic to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S.
Andreia Machado Brito-da-Costa +4 more
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Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. [PDF]
PLoS ONE, 2012 Cerebral hypoxia/ischemia (HI) is not uncommon during the perinatal period. If occurring, it can result in severe neurologic disabilities that persist throughout life.
Zhenhong Wang +4 more
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