Results 41 to 50 of about 136,276,834 (195)
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands [PDF]
, 2013 Salvinorin A, the active ingredient of the hallucinogenic plant Salvia divinorum is the most potent known naturally occurring hallucinogen and is a selective κ-opioid receptor agonist.
Polepally, Prabhakar R. +5 more
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DESIGN AND SYNTHESIS OF SALVINORIN-BASED COMPOUNDS FOR THE OPIOID RECEPTORS. [PDF]
, 2021 Opioid receptors (OR) are expressed throughout both the peripheral and central nervous system and play crucial roles in the modulation of antinociception, addiction, anxiety, and depression.
Akins, Nicholas S
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Studies Towards the Synthesis of Salvinorin A [PDF]
Australian Journal of Chemistry, 2006 Salvinorin A 1, a psychoactive neoclerodane diterpenoid from the Mexican sage S. divinorum, has gained interest as a selective ?-opioid receptor agonist. Non-racemic 3-furylamines 9a and 9b have been prepared from (+)-pseudoephedrine and (–)-ephedrine for application in the stereoselective synthesis of the ketone ring of 1.
Anthony R. Lingham +2 more
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Autoxidation of Salvinorin A under Basic Conditions
, 2016 Treatment of salvinorin A (1a) with KOH in MeOH gave the enedione 3, for which the dienone structure 7 was recently proposed. Also isolated, after methylation, were the secotriesters 4a−c. A mechanism for this unusual series of autoxidations is proposed.
Timothy A. Vortherms (2406421) +4 more
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Frontiers in Integrative Neuroscience, 2014 This article brings together three findings and ideas relevant for the understanding of human consciousness: (I) Crick's and Koch's theory that the claustrum is a conductor of consciousness center crucial for subjective conscious experience.
Klaus M Stiefel +2 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for ...
Chongguang Chen +5 more
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ChemistryOpen, Volume 15, Issue 9, September 2026.An endemic Aurès chemotype of Salvia balansae emerges as a rich source of luteolin, rosmarinic acid, and other polyphenols with potent antioxidant and NLRP3‐linked anti‐inflammatory activities. Protection against experimental inflammation, favorable enzyme‐modulating properties, and a wide safety margin highlight its promise as a pharmaceutical and ...
Khadra Afaf Bendrihem +16 more
wiley +1 more source
The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease
Gut Pathogens, 2022 Inflammatory bowel disease (IBD), a chronic gut immune dysregulation and dysbiosis condition is rapidly increasing in global incidence. Regardless, there is a lack of ideal diagnostic markers, while conventional treatment provides scarce desired results,
Xinwei Xu +8 more
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British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
, 2011 The effects of Salvinorin A, (Salvia divinorum principal ingredient), a potent k-opioid natural hallucinogen, on learning and memory were investigated. Wistar rats were tested in the 8-arm radial maze, for object recognition and passive avoidance tasks ...
V. Capurro +9 more
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