Results 51 to 60 of about 136,276,834 (195)
Molecular Pain, 2012 Background Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and
Guida Francesca +12 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 14, Page 4022-4047, July 2026.Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller +3 more
wiley +1 more source
Palladium-Catalyzed Transformations of Salvinorin A, a Neoclerodane Diterpene from Salvia divinorum [PDF]
, 2013 Transformations that selectively modify the furan ring present in a variety of naturals products would be useful in the synthesis of biological probes but remain largely underexplored.
Prisinzano, Thomas E. +7 more
core +1 more source
Substanţele psihoactive noi şi riscurile consumului la copii şi adolescenţi [PDF]
Romanian Journal of Pediatrics, 2019 Conform definiției stabilite de Monitorul European pentru Droguri şi Toxicomanie (European Monitoring Centre for Drugs and Drug Addiction – EMCDDA), o „substanță psihoactivă nouă este considerată orice substanță narcotică sau psihotropă în formă pură sau
Viorela Nițescu
doaj +1 more source
Kappa Opioids, Salvinorin A and Major Depressive Disorder [PDF]
Current Neuropharmacology, 2016 Opioids are traditionally associated with pain, analgesia and drug abuse. It is now clear, however, that the opioids are central players in mood. The implications for mood disorders, particularly clinical depression, suggest a paradigm shift from the monoamine neurotransmitters to the opioids either alone or in interaction with monoamine neurons.
Taylor, George T., Manzella, Francesca
openaire +2 more sources
New psychoactive substances and the risks of consumption in children and adolescents [PDF]
Romanian Journal of Pediatrics, 2019 According to the definition established by the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) a “new psychoactive substance is considered any narcotic or psychotropic substance in pure form or in preparations, which is not controlled by
Viorela Nitescu
doaj +1 more source
徐州医科大学学报Objective To investigate the antiepileptic effects of the natural κ-opioid receptor (KOR) agonist Salvinorin A (SA) on pilocarpine-induced chronic epileptic mice and to explore the underlying mechanisms.Methods A total of 45 male 8-week-old C57BL/6J mice
CAI Jiheng +4 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges
Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou +7 more
wiley +1 more source
Synthesis of Salvinorin A Analogues as Opioid Receptor Probes [PDF]
Journal of Natural Products, 2006 Several neoclerodanes, such as salvinorin A (1) and herkinorin (3), have recently been shown to possess opioid receptor activity in vitro and in vivo. To explore the structure-affinity relationships of this interesting class of compounds, we have synthesized a series of analogues from 1 isolated from Salvia divinorum.
Kevin, Tidgewell +10 more
openaire +2 more sources