Results 61 to 70 of about 136,276,834 (195)
10-step Synthesis of 20-nor-Salvinorin A by Dynamic Strategic Bond Analysis [PDF]
, 2017 Salvinorin A (SalA) is a plant metabolite that agonizes the human kappa-opioid receptor (κ-OR) with high affinity and high selectivity over mu- and delta-opioid receptors.
Vsevolod, Katritch +7 more
core +1 more source
Exploring natural products for insomnia: Effective solutions for better sleep
Sleep Research, Volume 2, Issue 3, Page 145-165, September 2025.Abstract Insomnia, affecting millions worldwide, is a prevalent sleep disorder characterized by persistent difficulties in both initiating and maintaining sleep, leading to compromised daytime functioning, heightened risks of cardiovascular and psychiatric comorbidities, and substantial socioeconomic burdens necessitating the pursuit of safer and more ...
Yingjie Cai +5 more
wiley +1 more source
Revista Brasileira de Plantas Medicinais, 2010 A planta Salvia divinorum Epling & Játiva (SDI), da família Lamiaceae, tem sido usada por séculos pela cultura mazateca e vem ganhando popularidade como droga recreacional nos últimos anos.
R.J. Schneider, P. Ardenghi
doaj +1 more source
Genetics‐Based Targeting Strategies for Precise Neuromodulation
Advanced Science, Volume 12, Issue 28, July 24, 2025.In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He +11 more
wiley +1 more source
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
Harnessing Pharmacogenomics in Clinical Research on Psychedelic‐Assisted Therapy
Clinical Pharmacology &Therapeutics, Volume 117, Issue 1, Page 106-115, January 2025.Psychedelics have recently re‐emerged as potential treatments for various psychiatric conditions that impose major public health costs and for which current treatment options have limited efficacy. At the same time, personalized medicine is increasingly being implemented in psychiatry to provide individualized drug dosing recommendations based on ...
Andreas Halman +5 more
wiley +1 more source
Chemical syntheses of the salvinorin chemotype of KOR agonist
Natural Product Reports, 2020 Chemical syntheses of the salvinorin chemotype analyzed through the lens of chemical space navigation.
Sarah J. Hill +2 more
openaire +3 more sources
Asymmetric Synthesis of Salvinorin A, A Potent κ Opioid Receptor Agonist
, 2016 The stereoselective synthesis of salvinorin A is described.
Jonathan R. Scheerer (1676254) +3 more
core +1 more source
Molecular Informatics, Volume 44, Issue 1, January 2025.Abstract Diseases caused by viruses are challenging to contain, as their outbreak and spread could be very sudden, compounded by rapid mutations, making the development of drugs and vaccines a continued endeavour that requires fast discovery and preparedness. Targeting viral infections with small molecules remains one of the treatment options to reduce
Jude Y. Betow +7 more
wiley +1 more source
Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes. [PDF]
, 2017 The field of salvinorin chemistry represents a novel and emerging field of opioid research. The novelty is derived from the lead pharmacophore: salvinorin A — a neoclerodane diterpenoid natural product isolated from Salvia divinorum.
Keasling, Adam
core +1 more source