Quantitative determination of salvinorin A, a natural hallucinogen with abuse liability, in Internet-available Salvia divinorum and endemic species of Salvia in Taiwan [PDF]
, 2014 In recent years, recreational use of Salvia divinorum (Lamiaceae), a herbal drug that contains a hallucinogenic ingredient, salvinorin A, has become a new phenomenon among young drug users.
Chang, Hsien-Chang +13 more
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A Report of Nausea and Vomiting with Discontinuation of Chronic Use of Salvia divinorum
Case Reports in Medicine, 2012 Introduction. This is the first reported case of gastrointestinal symptoms associated with withdrawal after chronic use of this substance. Case Presentation.
C. R. Travis, G. A. Ray, K. F. Marlowe
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Chemogenetic Tools in Focus: Proximity, Conformation, and Sterics
Chemistry–Methods, Volume 4, Issue 6, June 2024.Chemogenetic tools have been widely applied to interrogate dynamic biological processes. They are genetically encoded systems that are controlled by user‐defined chemicals. In this review, chemogenetic tool designs for various biological applications are introduced and discussed.
Jiaqi Shen, Guanwei Zhou, Wenjing Wang
wiley +1 more source
Salvinorin A impairs memory function in rats : role of endocannabinoid system
, 2008 Salvia divinorum is a recreational drug known to induce hallucinatory effects (1). Its main active ingredient, salvinorin A, has been recently found to have reinforcing effects in rats (2).
V. Capurro +5 more
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Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action
Journal of Pain Research, 2019 Ulises Coffeen, Francisco Pellicer Research in Neurosciences, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, México Abstract: Salvia divinorum is a herbal plant native to the southwest region of ...
Coffeen U, Pellicer F
doaj
Synthesis of Heterocyclic Analogues of Salvinorin A
, 2006 The unique opioid salvinorin A is isolated from the known psychoactive plant Salvia divinorum. This plant is currently being sold on the internet as a legal hallucinogen.
Prisinzano, Thomas E. +5 more
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Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorin A and B [PDF]
, 2007 To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural κ-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity.
Yan, Feng +3 more
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A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
Frontiers in Pharmacology, 2019 Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or ...
Kendall L. Mores +6 more
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Differential Helical Orientations among Related G Protein-coupled Receptors Provide a Novel Mechanism for Selectivity: STUDIES WITH SALVINORIN A AND THE κ-OPIOID RECEPTOR [PDF]
, 2007 Salvinorin A, the active component of the hallucinogenic sage Salvia divinorum, is an apparently selective and highly potent kappa-opioid receptor (KOR) agonist.
Vortherms, Timothy A. +3 more
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Palladium-Catalyzed Transformations of Salvinorin A, a Neoclerodane Diterpene from Salvia divinorum
, 2016 Transformations that selectively modify the furan ring present in a variety of naturals products would be useful in the synthesis of biological probes but remain largely underexplored.
Victor W. Day (1312500) +3 more
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