Results 91 to 100 of about 136,276,834 (195)

Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids [PDF]

, 2011
The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported.
Lewellyn, Kevin, Yan, Feng, Kevin Lewellyn, Jordan K. Zjawiony, Jakub Fichna, Feng Yan, Roth, Bryan L., Zjawiony, Jordan K., Bryan L. Roth, Fichna, Jakub   +9 more
core   +1 more source

Total Synthesis of the Hallucinogenic Neoclerodane Diterpenoid Salvinorin A

, 2016
Total synthesis of salvinorin A (1), a neoclerodane diterpenoid having the most potent hallucinogenic activity and a selective κ-opioid agonist, was completed in 20 steps starting from enantiomerically pure hydroxy-Wieland−Miescher ketone ...
Hisahiro Hagiwara (1883416), Takashi Hoshi (1883410), Masato Nozawa (2445649), Toshio Suzuki (1883407), Yuhki Suka (2445646)   +4 more
core   +1 more source

Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice: Salvinorin A analogues PR-37 and PR-38 in pruritus [PDF]

, 2015
The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain.
Fichna, J., Sacharczuk, M., Salaga, M., Sobczak, K., Zjawiony, J. K., Polepally, P. R., Zielinska, M., Do Rego, J. C., Roth, B. L., Murawska, N., Marynowski, M., Fabisiak, A.   +11 more
core   +1 more source

Salvinorin A administration blocked the elevated CSF ERK activity observed 1 h after HI.

, 2013
The ration of pERK/ERK at 1 hour after HI in the control groups (n = 10, DMSO and nor-BIN groups) increased significantly compared with the baseline. The baseline for all the groups are pulled together (n = 20) and the data from DMSO and nor-BIN groups ...
Zhenhong Wang (314457), Nan Ma (314032), Renyu Liu (184348), William M. Armstead (314461), John Riley (314459)   +4 more
core   +1 more source

The Synthesis and Pharmacological Evaluation of Salvinorin A Analogues as Opioid Receptor Probes [PDF]

, 2011
Kappa opioid (KOP) receptors have been shown to be involved in the control of several abuse related effects of central nervous system stimulants. KOP receptor agonists have been shown to modulate the activity of dopamine neurons and decrease self ...
Lovell, Kimberly M.
core   +1 more source

Emotional response induced by salvinorin A and D9–tetrahydrocannabinol (THC) is mediated by k-opioid and CB1 cannabinoid receptor in rats

, 2007
Salvinorin A, a potent k-opioid receptor agonist (Roth et al., 2002), is the major active ingredient of Salvia divinorum, the abuse of which has greatly increased in recent years for its hallucinogenic effects.
V. Capurro, A. Zani, D. Braida, M. Sala
core   +1 more source

Evaluation of Interactions Between Transient Receptor Potential Vanilloid 1 and Active Constituents Using Molecular Docking

Dubai Medical Journal
Introduction: Pain, whether acute or chronic, imposes huge economic burdens in the societies due to complexities in the signaling pathways that lead to pain.
Sahar Jaffal, Salman Khan, Muhammad Ibrar Khan   +2 more
doaj   +1 more source

Unconditioned Behavioral Effects of the Powerful -Opioid Hallucinogen Salvinorin A in Nonhuman Primates: Fast Onset and Entry into Cerebrospinal Fluid

, 2020
Salvinorin A is the main active component of the widely available hallucinogenic plant, Salvia divinorum. Salvinorin A is a selective high-efficacy -agonist in vitro, with some unique pharmacodynamic properties. Descriptive reports show that salvinorin A-
Szymon Rus, Thomas E Prisinzano, Eduardo R Butelman, Mary Jeanne Kreek, Haiteng Deng   +4 more
core  

Chemogenomics Knowledgebase and Systems Pharmacology for Hallucinogen Target Identification -Salvinorin A as a Case Study [PDF]

, 2015
Drug abuse is a serious problem worldwide. Recently, hallucinogens have been reported as a potential therapy for substance abuse. However, the use of hallucinogens as a drug abuse treatment itself has potential risks. The true mechanisms of hallucinogens
Xu, Xiaomeng
core  

Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels–Alder Strategy

, 2018
A concise total synthesis of the neoclerodane diterpene salvinorin A from 3-furaldehyde is reported using two highly diastereoselective intramolecular Diels–Alder reactions (IMDA) as the key ...
Yuzhou Wang (600730), Peter Metz (2849501)   +1 more
core   +1 more source