Results 71 to 80 of about 136,276,834 (195)
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach
Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
Marie Emilie Hovah, Ulrike Holzgrabe
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The Plant Journal, Volume 120, Issue 3, Page 984-997, November 2024.SUMMARY The Lamiaceae (mint family) is the largest known source of furanoclerodanes, a subset of clerodane diterpenoids with broad bioactivities including insect antifeedant properties. The Ajugoideae subfamily, in particular, accumulates significant numbers of structurally related furanoclerodanes.
Nicholas J. Schlecht +5 more
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Salvinorin A: beyond partial synthesis
, 2023 Thomas Munro - Salvinorin A: beyond partial synthesis (psychedelic molecules, 4th-5th September 2023, Prague, Czech Republic)
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2013 The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket ...
Thomas A. Munro +4 more
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Molecules, 2018 The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A), a
Bronwyn M. Kivell +9 more
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Prediction of storage years of Wuyi rock tea Shuixian by metabolites analysis
Food Science &Nutrition, Volume 12, Issue 10, Page 7166-7176, October 2024.A total of 1201 compounds were detected from shuixian by UPLC‐Q‐TOF‐MS. Twenty‐nine potential marker compounds were selected to identify the age of shuixian. Fifteen years of storage is the inflection point of tea. Abstract Wuyi rock teas of different storage duration have different flavor, bioactivity, and market value, Shuixian is a main variety of ...
Xiaoyue Song +4 more
wiley +1 more source
Novel Opioids Based on Salvinorin A
, 2008 The Mexican mint Salvia divinorum (Lamiaceae) has been gaining legal attention due to its hallucinogenic effects. These effects have been attributed to salvinorin A, a major metabolite of this plant.
Prisinzano, Thomas E. +6 more
core
, 2007 Salvinorin A, a potent kappa-opioid receptor agonist (1) is the major active ingredient of Salvia divinorum,a hallucinogenic herb, usually smoked or buccally absorbed by chewing. Recently, salvinorin A has been shown to produce reinforcing effects in the
V. Capurro, A. Zani, D. Braida, M. Sala
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Revisiting dezocine for opioid use disorder: A narrative review of its potential abuse liability
CNS Neuroscience &Therapeutics, Volume 30, Issue 9, September 2024.Dezocine is a partial MOR agonist previously used clinically in the USA and currently in China. It has been proposed that dezocine be reintroduced to clinical use in the USA, as an analgesia and/or an additional tool to treat opioid use disorder. To consider the clinical reintroduction of dezocine knowing its abuse liability is important.
Gordon A. Barr +4 more
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Physiologia Plantarum, Volume 176, Issue 5, September/October 2024.Abstract Salvia divinorum is a hallucinogenic plant native to the Oaxaca in Mexico. The active ingredient for psychotropic effects in this plant is salvinorin A, a potent and highly selective κ‐opioid receptor agonist. Salvinorin A is distinct from other well‐known opioids, such as morphine and codeine, in that it is a non‐nitrogenous diterpenoid with ...
Iris Ngo +5 more
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