Results 31 to 40 of about 136,276,834 (195)
Frontiers in Pharmacology, 2015 Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the ...
Eduardo eButelman, Mary Jeanne eKreek
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Brazilian Journal of Medical and Biological Research, 2018 This study aimed to investigate the protective effect of salvinorin A on the cerebral pial artery after forebrain ischemia and explore related mechanisms. Thirty Sprague-Dawley rats received forebrain ischemia for 10 min.
H.P. Dong +4 more
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Molecules, 2023 The natural product Salvinorin A (SalA) was the first nitrogen-lacking agonist discovered for the opioid receptors and exhibits high selectivity for the kappa opioid receptor (KOR) turning SalA into a promising analgesic to overcome the current opioid ...
Kristina Puls, Gerhard Wolber
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Unambiguous NMR spectral assignments of salvinorin A [PDF]
Magnetic Resonance in Chemistry, 2007 AbstractThe complete assignments of the 1H and 13C NMR spectra of the hallucinogenic neoclerodane diterpenoid salvinorin A were determined in three different NMR solvents using HSQC, HMBC and COSY. Solvent systems are described that allow the resolution of all 1H signals.
José-Luis, Giner +3 more
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Frontiers in Psychiatry, 2019 Over the years, pain has contributed to low life quality, poor health, and economic loss. Opioids are very effective analgesic drugs for treating mild, moderate, or severe pain.
Jordan K. Zjawiony +12 more
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Frontiers in Pharmacology, 2022 Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a promising alternative to currently available opioid drugs due to their low abuse ...
Kelly F. Paton +5 more
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Evaluation of Biased and Balanced Salvinorin A Analogs in Preclinical Models of Pain
Frontiers in Neuroscience, 2020 In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential.
Kelly F. Paton +8 more
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Salvinorin A Analogs as Probes in Opioid Pharmacology [PDF]
Chemical Reviews, 2008 The opium poppy, Papaver somniferum, is one of several plants that have profoundly affected human history.1 It has provided an unmatched medicine for the relief of pain for centuries.2 More than 30 alkaloids have been identified in opium, and among the most relevant are morphine (1a) and codeine (1b) (Figure 1).3 These alkaloids are important for ...
Thomas E, Prisinzano, Richard B, Rothman
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IOP Conference Series: Earth and Environmental Science, 2020 Abstract Salvia divinorum plants were exposed to a synthetic atmosphere containing 600 ppm 13CO2 for 4 hours with white light illumination and were subsequently cultured for a chase period of 10 days under standard greenhouse conditions.
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Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Biomedicines, 2021 In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus.
Yeon Sun Lee +10 more
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