Results 11 to 20 of about 136,276,834 (195)

Salvinorin A Does Not Affect Seizure Threshold in Mice [PDF]

Molecules, 2020
The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy.
Katarzyna Socała, Urszula Doboszewska, Piotr Wlaź   +2 more
doaj   +4 more sources

Formal Total Synthesis of Salvinorin A [PDF]

ChemistryOpen, 2022
The generation of the quaternary stereocenter at the C9 position of salvinorin A precursors by the Claisen rearrangement was investigated. The required allyl alcohol was prepared from a Wieland‐Miescher ketone using a known γ‐hydroxylation, reduction of ...
Marc Halang, Prof. Dr. Martin E. Maier
doaj   +3 more sources

A Route to Potent, Selective, and Biased Salvinorin Chemical Space [PDF]

ACS Central Science, 2023
The salvinorins serve as templates for next generation analgesics, antipruritics and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selectivity via complex polyoxygenated scaffolds that have frustrated deep ...
Sarah J. Hill, Nathan Dao, Vuong Q. Dang, Edward L. Stahl, Laura M. Bohn, Ryan A. Shenvi   +5 more
doaj   +5 more sources

Autoxidation of Salvinorin A under Basic Conditions [PDF]

The Journal of Organic Chemistry, 2005
[reaction: see text] Treatment of salvinorin A (1a) with KOH in MeOH gave the enedione 3, for which the dienone structure 7 was recently proposed. Also isolated, after methylation, were the secotriesters 4a-c. A mechanism for this unusual series of autoxidations is proposed.
Thomas A, Munro, Glenn W, Goetchius, Bryan L, Roth, Timothy A, Vortherms, Mark A, Rizzacasa   +4 more
openaire   +3 more sources

The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis [PDF]

Frontiers in Neurology, 2021
Multiple sclerosis is a neurodegenerative disease associated with demyelination and neuroinflammation in the central nervous system. There is an urgent need to develop remyelinating therapies to better treat multiple sclerosis and other demyelinating ...
Kelly F. Paton, Kelly F. Paton, Katharina Robichon, Katharina Robichon, Nikki Templeton, Nikki Templeton, Lisa Denny, Lisa Denny, Afnan Al Abadey, Afnan Al Abadey, Dan Luo, Thomas E. Prisinzano, Anne C. La Flamme, Anne C. La Flamme, Anne C. La Flamme, Bronwyn M. Kivell, Bronwyn M. Kivell   +16 more
doaj   +4 more sources

8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

Beilstein Journal of Organic Chemistry, 2007
There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds.
Thomas A. Munro, Katharine K. Duncan, Richard J. Staples, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon Jr., Bruce M. Cohen   +7 more
doaj   +2 more sources

Salvinorin B methoxymethyl ether [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
The title compound [MOM-SalB; systematic name: methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-fur-yl)-9-meth-oxy-meth-oxy-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octa-hydro-1H-benzo[f]isochromene-7-carboxyl-ate], C(23)H(30)O(8), is a deriv-ative of the κ-opioid salvinorin A with enhanced potency, selectivity, and duration of action.
Munro, Thomas A., Ho, Douglas M., Cohen, Bruce   +2 more
openaire   +6 more sources

Unusual hemiacetal structure derived from Salvinorin A [PDF]

Acta Crystallographica Section E, 2008
The salvinorin A analog dimethyl (2R,3aR,4R,6aR,7R,9S,9aS,9bS)-2-(3-furyl)-9,9a-dihydroxy-3a,6a-dimethyldodecahydrobenzo[de]chromene-4,7-dicarboxylate, C22H30O8, has a relatively simple spatial arrangement in which molecules are linked into layers by two
Paulo Carvalho, Ruslan Bikbulatov, Jordan K. Zjawiony, Mitchell A. Avery   +3 more
doaj   +3 more sources

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction. [PDF]

Food Sci Nutr
Phytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Boudou F, Berkane A, Belakredar A, Keziz A, Alsaeedi H, Murray BA, Bechelany M, Barhoum A.   +7 more
europepmc   +2 more sources

Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa-Opioid and 5-HT_2A _/2C Receptor Agonists in Mice. [PDF]

Neuropsychopharmacol Rep
This study developed a simple way to test new psychoactive substances (NPS) in mice. Two drugs, U50,488H and DOI caused aversive and abnormal behaviors in mice, likely linked to their hallucinogenic properties. These results suggest such behavioral tests could help quickly identify and regulate harmful psychoactive drugs. ABSTRACT Aim The regulation of
Kato H, Ichimaru Y, Kurihara M, Sogawa K, Funada M, Suzuki T.   +5 more
europepmc   +2 more sources