Reaction Enumeration Based on NBO-Informed Molecular Graphs. [PDF]
J Comput ChemNBO‐informed molecular graphs represent chemistry via valence orbitals rather than atomic connectivity, enabling consistent reaction analysis across environments. By identifying delocalized motifs and increasing complexity adaptively, the framework enables efficient exploration of inaccessible mechanisms and diverse catalytic and reaction networks for ...
Alfonso-Ramos JE, Stuyver T.
europepmc +2 more sources
The Kappa Opioid Receptor and the Sleep of Reason:Cortico-Subcortical Imbalance Following Salvinorin-A [PDF]
, 2021 Background: The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use.
Romero, S. +44 more
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Salvinorin A inhibits ovalbumin‐stimulated allergic rhinitis and RBL‐2H3 cells degranulation
FEBS Open Bio, 2021 Allergic rhinitis (AR) is a long‐term noncommunicable inflammatory disease of the nasal mucosa mediated by immunoglobulin E and is mainly caused by exposure of genetically susceptible individuals to environmental allergens.
Qiyang Shou, Tao Tan, Faying Xu
doaj +1 more source
Author Correction: The influence of cultivation conditions on the formation of psychoactive salvinorin A, salvinorin B, rosmarinic acid and caffeic acid in Coleus scutellarioides [PDF]
Scientific ReportsMaciej Jakobina +3 more
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Salvinorin A inhibits airway hyperreactivity induced by ovalbumin sensitization [PDF]
, 2017 Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system.
Pagano E. +10 more
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Addiction Neuroscience, 2022 Substance use disorder (SUD) is a global public health concern that affects millions of people worldwide. Considering current research, addiction has been noted as the last stage of a chronic disease that may impair brain reward circuit responses and ...
Fúlvio Rieli Mendes +5 more
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A Protecting‐Group‐Free Synthesis of (−)‐Salvinorin A
Chemistry – A European Journal, 2021 AbstractA concise enantioselective total synthesis of the neoclerodane diterpene (−)‐salvinorin A is reported. The stereogenic center at C‐12 was installed by catalytic asymmetric propargylation with excellent enantioselectivity, and the remaining six stereogenic centers were set up highly diastereoselectively under substrate control.
Patrick Zimdars, Yuzhou Wang, Peter Metz
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The Absolute Stereochemistry of Salvinorins [PDF]
Chemistry Letters, 1990 Abstract The absolute stereostructures of the hallucinogenic diterpenes salvinorin A and B have been unambiguously determined by the use of the non-empirical exciton chirality circular dichroism method on their 1α,2α-diol dibenzoate derivative.
Masato Koreeda +2 more
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Molecules, 2023 Kappa opioid receptor (KOR) agonists have preclinical antipsychostimulant effects; however, adverse side effects have limited their therapeutic development. In this preclinical study, conducted in Sprague Dawley rats, B6-SJL mice, and non-human primates (
Ross van de Wetering +8 more
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The analgesic and anti‐inflammatory effects of Salvinorin A analogue β‐tetrahydropyran Salvinorin B in mice [PDF]
European Journal of Pain, 2017 AbstractBackgroundDrugs activating the mu opioid receptor are routinely used to treat severe acute and chronic pain. Unfortunately, side effects including nausea, constipation, respiratory depression, addiction and tolerance can limit clinical utility.
K F, Paton +5 more
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