Results 1 to 10 of about 5,932,890 (256)

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes

Pharmaceutics, 2023
Salvianolic acid B is extracted from the roots and rhizomes of Danshen (Salvia miltiorrhiza Bge., family Labiatae). It is a water-soluble, weakly acidic drug that has demonstrated antitumor and anti-inflammatory effects on various organs and tissues such
Guannan He, Guangfeng Chen, Weidong Liu, Dongxue Ye, Xuehuan Liu, Xiaodong Liang, Jing Song   +6 more
doaj   +4 more sources

Gibberellin-Induced Transcription Factor SmMYB71 Negatively Regulates Salvianolic Acid Biosynthesis in Salvia miltiorrhiza [PDF]

Molecules
Salvia miltiorrhiza, the valuable traditional Chinese medicinal plant, has been used in clinics for thousands of years. The water-soluble salvianolic acid compounds are bioactive substances used in treating many diseases.
Cuicui Han, Xingwen Dong, Xiaowen Xing, Yun Wang, Xiaobing Feng, Wenjuan Sang, Yifei Feng, Luyao Yu, Mengxuan Chen, Hongyuan Hao, Taohong Huang, Bailin Li, Wenhui Wu, Zheng Zhou, Ying He   +14 more
doaj   +3 more sources

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [PDF]

Sci Rep
Intracerebral hemorrhage (ICH) is a common cerebral vascular disease with high incidence, disability, and mortality. Ferroptosis is a regulated type of iron-dependent, non-apoptotic programmed cell death. There is increasing evidence that ferroptosis may
Shi Y, Yan D, Nan C, Sun Z, Zhuo Y, Huo H, Jin Q, Yan H, Zhao Z.   +8 more
europepmc   +5 more sources

Neuroprotective Effects of Geopung-Chunghyuldan Based on Its Salvianolic Acid B Content Using an In Vivo Stroke Model

Current Issues in Molecular Biology, 2023
Background: Geopung-Chunghyuldan (GCD) has neuroprotective properties. Salviae miltiorrhizae Radix plays an essential role in GCD’s effect. The Salviae miltiorrhizae Radix marker compound is salvianolic acid B; however, its content is not uniform among ...
Han-Gyul Lee, Seungwon Kwon, Sang-Kwan Moon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho   +8 more
doaj   +2 more sources

Anticancer effects of salvianolic acid A through multiple signaling pathways (Review). [PDF]

Mol Med Rep
Salvia miltiorrhiza Bunge (Salvia miltiorrhiza), commonly referred to as Danshen, is a well-known herb in traditional Chinese medicine, the active ingredients of which are mostly categorized as water soluble and lipid soluble.
Li CX, Xu Q, Jiang ST, Liu D, Tang C, Yang WL.   +5 more
europepmc   +2 more sources

Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection

Frontiers in Pharmacology, 2023
Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by enterovirus (EV) infection. EV71 is one of the major pathogens causing hand, foot, and mouth disease and is more likely to cause exacerbation and death than other ...
Sai Shi, Lei Xie, Sen Ma, Binghong Xu, Hailong An, Sheng Ye, Yaxin Wang   +6 more
doaj   +2 more sources

Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial

Frontiers in Pharmacology, 2023
Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy.
Junlin Cheng, Jun Long, Jingjing Zhang, Le Han, Yunfang Hu, Jianghui Liu, Runze Qiu, Zhibin Zhu, Hongwei Fan   +8 more
doaj   +2 more sources

Ultrasonic-assisted nanofiltration separation recovering salvianolic acid B from ethanol wastewater

Ultrasonics Sonochemistry
The transformation of salvianolic acid B brought on by heat treatment recovery of ethanol eluent, which is a difficult problem in pharmaceutical technology, affects the purity of raw material when the medicinal raw material salvianolic acid B is purified
Cunyu Li, Yun Ma, Yangyang Xu, Ranyun Qiu, Xin Shen, Lulu Huang, Anrong Liu, Mingming Li, Yunfeng Zheng, Xinglei Zhi   +9 more
doaj   +2 more sources

Repurposing SARS CoV 2 ligands identifies salvianolic acid C as potential antiviral candidate against human metapneumovirus through computational study [PDF]

Scientific Reports
Human Metapneumovirus (HMPV) is a leading cause of respiratory tract infections worldwide, with no approved antiviral treatments or vaccines currently available.
Pallavi Mosale Shanthappa, Nidheesh Melethadathil, Shiva Prasad Kollur   +2 more
doaj   +2 more sources

Recent Advances in Transcription Factor–Mediated Regulation of Salvianolic Acid Biosynthesis in Salvia miltiorrhiza [PDF]

Plants
Salvia miltiorrhiza Bunge is a traditional Chinese medicinal plant whose roots are rich in water-soluble phenolic acids. Rosmarinic acid and salvianolic acid B are representative components that confer antibacterial, antioxidant, and cardio ...
Song Chen, Fang Peng, Shan Tao, Xiufu Wan, Hailang Liao, Peiyuan Wang, Can Yuan, Changqing Mao, Xinyi Zhao, Chao Zhang, Bing He, Mingzhi Zhong   +11 more
doaj   +2 more sources