Results 11 to 20 of about 5,932,890 (256)

Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway

Phytomedicine, 2022
Renal interstitial fibrosis (RIF) is the main pathological feature of end-stage renal disease (ESRD) caused by various chronic kidney diseases (CKD), and is closely related to renal dysfunction and patient prognosis. Salvianolic acid A (Sal A) and salvianolic acid B (Sal B), isolated from traditional Chinese medicine Salviae miltiorrhizae, have been ...
Lan, Yao, Renjie, Zhao, Shiyang, He, Qi, Feng, Yingjin, Qiao, Pei, Wang, Jun, Li   +6 more
openaire   +4 more sources

Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Pharmaceutics, 2020
Psoriasis is a chronic inflammatory skin disorder with a pathogenesis involving the interleukin-23/interleukin-17 axis. Salvianolic acid B exerts several pharmacological effects, such as antioxidation, anti-inflammation, and antitumor effects.
Jiun-Wen Guo, Yu-Pin Cheng, Chih-Yi Liu, Haw-Yueh Thong, Chi-Jung Huang, Yang Lo, Chen-Yu Wu, Shiou-Hwa Jee   +7 more
doaj   +3 more sources

Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots

Journal of Advanced Research, 2020
Salvia miltiorrhiza Bunge is an herb rich in bioactive tanshinone and salvianolic acid compounds. It is primarily used as an effective medicine for treating cardiovascular and cerebrovascular diseases.
Xiaolong Hao, Zhongqiang Pu, Gang Cao, Dawei You, Yang Zhou, Changping Deng, Min Shi, Shivraj Hariram Nile, Yao Wang, Wei Zhou, Guoyin Kai   +10 more
doaj   +3 more sources

Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis

Redox Biology
Hepatocyte ferroptosis promotes the pathogenesis and progression of liver fibrosis. Salvianolic acid B (Sal B) exerts antifibrotic effects. However, the pharmacological mechanism and target has not yet been fully elucidated. In this study, liver fibrosis
Yadong Fu, Xiaoxi Zhou, Lin Wang, W. Fan, Si-Qi Gao, Dan-Dan Zhang, Z. Ling, Yaguang Zhang, Liyan Ma, Fang Bai, Jiamei Chen, Bing Sun, Ping Liu   +12 more
semanticscholar   +3 more sources

Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells

Bioengineered, 2022
Endothelial dysfunction is a critical mediator in the pathogenesis of vascular complications of diabetes. Herein, this study was conducted to investigate the therapeutic effects of Salvianolic acid B (Sal B) on diabetes-induced endothelial dysfunction ...
Jie Xiang, Chunling Zhang, Tietao Di, Lu Chen, Wei Zhao, Liang Wei, Shiyong Zhou, Xueli Wu, Gengxin Wang, Yun Zhang   +9 more
semanticscholar   +3 more sources

Targeting post-stroke neuroinflammation with Salvianolic acid A: molecular mechanisms and preclinical evidence. [PDF]

Front Immunol
Salvianolic acid A (SalA), a bioactive compound extracted from Salvia miltiorrhiza, has garnered considerable interest for its potential in ameliorating the post-stroke neuroinflammation.
Yang H, Ibrahim MM, Zhang S, Sun Y, Chang J, Qi H, Yang S.   +6 more
europepmc   +2 more sources

Nanopore analysis of salvianolic acids in herbal medicines

Nature Communications
Natural herbs, which contain pharmacologically active compounds, have been used historically as medicines. Conventionally, the analysis of chemical components in herbal medicines requires time-consuming sample separation and state-of-the-art analytical ...
Pingping Fan, Shanyu Zhang, Yuqin Wang, Tian Li, Hanhan Zhang, Panke Zhang, Shuo Huang   +6 more
doaj   +3 more sources

Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection [PDF]

Journal of Biomedical Science, 2011
Salvianolic acids are the most abundant water-soluble compounds extracted from Radix Salvia miltiorrhiza (Danshen). In China, Danshen has been wildly used to treat cardiovascular diseases for hundreds of years.
Ho Jennifer, Hong Chuang-Ye
doaj   +3 more sources

Salvianolic acid B: a promising cardioprotective agent. [PDF]

Front Immunol
Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is a core herb in traditional Chinese medicine widely used for treating cardiovascular diseases (CVD). Its key bioactive compound, salvianolic acid B (SalB), has emerged as a promising therapeutic agent for CVD.
Shao Y, Zhai L, Jiang S, Sun F, Liu X.
europepmc   +2 more sources

Cardiovascular Effects of Salvianolic Acid B [PDF]

Evidence-Based Complementary and Alternative Medicine, 2013
Salvianolic acid B (SAB, Sal B) is the representative component of phenolic acids derived from the dried root and rhizome ofSalvia miltiorrhizaBge (Labiatae) which has been used widely and successfully in Asian countries for clinical therapy of various vascular disturbance-related diseases for hundreds of years.
Wang, Jie, Xiong, Xingjiang, Feng, Bo
openaire   +3 more sources