Results 81 to 90 of about 5,932,890 (256)

Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI

Journal of Pharmaceutical Analysis, 2022
Salvia miltiorrhiza Bge (SMB) has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases. Growing clinical usage has led to a huge demand for artificial planting of SMB.
Chenglong Sun, Li Cui, Bingqian Zhou, Xiao Wang, Lanping Guo, Wei Liu   +5 more
doaj   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Mentha spicata L. infusions as sources of antioxidant phenolic compounds: emerging reserve lots with special harvest requirements [PDF]

, 2016
Mentha spicata L., commonly known as spearmint, is widely used in both fresh and dry forms, for infusion preparation or in European and Indian cuisines.
Barros, Lillian, Ferreira, Isabel C.F.R., Pereira, Carla, Rita, Íngride, Santos-Buelga, Celestino   +4 more
core   +1 more source

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site

Research and Practice in Thrombosis and Haemostasis
Background Salvianolic acid B (SAB) is a major component of Salvia miltiorrhiza root (Danshen), widely used in East/Southeast Asia for centuries to treat cardiovascular diseases.
Miguel A. D. Neves, Tiffany Ni, Daniel T. MacKeigan, Aron A. Shoara, X. Lei, S. Slavkovic, Si-yang Yu, Tyler W Stratton, Reid C. Gallant, Dan Zhang, X. Xu, C. Fernandes, G. Zhu, Xudong Hu, Noa Chazot, Logan W. Donaldson, P. Johnson, Kim Connelly, Margaret L. Rand, Yiming Wang, Heyu Ni   +20 more
semanticscholar   +1 more source

Network Pharmacology and Molecular Docking-Based Mechanism Study to Reveal the Protective Effect of Salvianolic Acid C in a Rat Model of Ischemic Stroke

Frontiers in Pharmacology, 2022
Salvianolic acid C (SAC) is a major bioactive component of Salvia miltiorrhiza Bunge (Danshen), a Chinese herb for treating ischemic stroke (IS). However, the mechanism by which SAC affects the IS has not yet been evaluated, thus a network pharmacology ...
Yuting Yang, Yu He, Xiaoyu Wei, H. Wan, Zhishan Ding, Jiehong Yang, Huifen Zhou   +6 more
semanticscholar   +1 more source

Salvianolic acid B stimulates osteogenesis in dexamethasone-treated zebrafish larvae [PDF]

Acta Pharmacologica Sinica, 2016
Our previous studies show that salvianolic acid B (Sal B) promotes osteoblast differentiation and matrix mineralization. In this study, we evaluated the protective effects of Sal B on the osteogenesis in dexamethasone (Dex)-treated larval zebrafish, and elucidated the underlying mechanisms.At 3 d post fertilization, wild-type AB zebrafish larvae or ...
Shi-Ying, Luo, Jing-Feng, Chen, Zhi-Guo, Zhong, Xiao-Hua, Lv, Ya-Jun, Yang, Jing-Jing, Zhang, Liao, Cui   +6 more
openaire   +2 more sources

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

A mussel-inspired, antibacterial, antioxidant, injectable composite hydrogel for the sustain delivery of salvianolic acid B for the treatment of frozen shoulder

Bioactive Materials
Frozen shoulder (FS) manifests as progressively worsening pain and a reduction in shoulder range of motion (ROM). Salvianolic acid B (SaB) is recently expected to be used in the treatment of fibrosis diseases including FS. We firstly demonstrate that SaB
Yan Yan, Xinhao Li, Chen Chen, Dedong Cui, Zhuo Wang, Ming Li, Yi Long, Jinming Zhang, Cheng Li, Zhiling Wang, Chuanhai Zhou, Zeyu Yao, Dan Wang, Jingyi Hou, Rui Yang   +14 more
semanticscholar   +1 more source

Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis

Frontiers in Pharmacology, 2022
Rescuing endothelial cells from pyroptotic cell death emerges as a potential therapeutic strategy to combat diabetic atherosclerosis. Salvianolic acid A (SAA) is a major water-soluble phenolic acid in the Salvia miltiorrhiza Bunge, which has been used in
Ji Zhu, Hang Chen, Yifei Le, Jianan Guo, Zhijun Liu, Xiaobing Dou, Dezhao Lu   +6 more
semanticscholar   +1 more source