Results 11 to 20 of about 19,711 (218)

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes

Pharmaceutics, 2023
Salvianolic acid B is extracted from the roots and rhizomes of Danshen (Salvia miltiorrhiza Bge., family Labiatae). It is a water-soluble, weakly acidic drug that has demonstrated antitumor and anti-inflammatory effects on various organs and tissues such
Guannan He, Guangfeng Chen, Weidong Liu, Dongxue Ye, Xuehuan Liu, Xiaodong Liang, Jing Song   +6 more
doaj   +3 more sources

Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway

Phytomedicine, 2022
Renal interstitial fibrosis (RIF) is the main pathological feature of end-stage renal disease (ESRD) caused by various chronic kidney diseases (CKD), and is closely related to renal dysfunction and patient prognosis. Salvianolic acid A (Sal A) and salvianolic acid B (Sal B), isolated from traditional Chinese medicine Salviae miltiorrhizae, have been ...
Lan, Yao, Renjie, Zhao, Shiyang, He, Qi, Feng, Yingjin, Qiao, Pei, Wang, Jun, Li   +6 more
openaire   +4 more sources

Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Pharmaceutics, 2020
Psoriasis is a chronic inflammatory skin disorder with a pathogenesis involving the interleukin-23/interleukin-17 axis. Salvianolic acid B exerts several pharmacological effects, such as antioxidation, anti-inflammation, and antitumor effects.
Jiun-Wen Guo, Yu-Pin Cheng, Chih-Yi Liu, Haw-Yueh Thong, Chi-Jung Huang, Yang Lo, Chen-Yu Wu, Shiou-Hwa Jee   +7 more
doaj   +3 more sources

Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots

Journal of Advanced Research, 2020
Salvia miltiorrhiza Bunge is an herb rich in bioactive tanshinone and salvianolic acid compounds. It is primarily used as an effective medicine for treating cardiovascular and cerebrovascular diseases.
Xiaolong Hao, Zhongqiang Pu, Gang Cao, Dawei You, Yang Zhou, Changping Deng, Min Shi, Shivraj Hariram Nile, Yao Wang, Wei Zhou, Guoyin Kai   +10 more
doaj   +3 more sources

Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo [PDF]

Frontiers in Pharmacology, 2020
Osteoarthritis (OA) is a degenerative disease found in middle-aged and elderly people, which seriously affects their quality of life. The anti-inflammatory and anti-apoptosis pharmacological effects of salvianolic acid A (SAA) have been shown in many ...
Yifan Wu, Zhanghong Wang, Zeng Lin, Xin Fu, Jingdi Zhan, Kehe Yu   +5 more
doaj   +3 more sources

Development of a Multienzyme Cascade for Salvianolic Acid A Synthesis from l-Tyrosine. [PDF]

ACS Omega
Salvianolic acid A (SAA) has an important application value for preventing and treating cardiovascular diseases. In this study, we developed a novel multienzyme cascade system for the efficient biosynthesis of SAA, utilizing l-tyrosine (l-Tyr) as a cost-effective and stable starting material. The cascade system incorporated four enzymes: membrane-bound
Zhang M, Zhong J, Zhang Y, Wang W, Zhao W, Hu S, Lv C, Huang J, Mei L.   +8 more
europepmc   +4 more sources

Salvianolic Acid Modulates Physiological Responses and Stress-Related Genes That Affect Osmotic Stress Tolerance in Glycine max and Zea mays

Frontiers in Plant Science, 2022
Drought is a serious threat worldwide to soybean and maize production. This study was conducted to discern the impact of salvianolic acid treatment on osmotic-stressed soybean (Glycine max L.) and maize (Zea mays L.) seedlings from the perspective of ...
Elham Ahmed Kazerooni, Abdullah Mohammed Al-Sadi, Umer Rashid, Il-Doo Kim, Sang-Mo Kang, In-Jung Lee   +5 more
doaj   +1 more source

Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds. [PDF]

, 2017
Previously, we only apply a traditional Chinese medicine (TCM) Danshen-Chuanxiong-Honghua (DCH) for cardioprotection via anti-inflammation in rats of acute myocardial infarction by occluding coronary artery. Presently, we select not only DCH but also its
Fushun Wang, Jian Wang, Ping Ren, Tingrui Wang, Wan Zheng, Xi Huang, Xi Huang, Xianhua Zhang, Xianhua Zhang, Xinliang Ma   +9 more
core   +10 more sources

Inhibitory Effect of Salvia miltiorrhiza Extract and Its Active Components on Cervical Intraepithelial Neoplastic Cells

Molecules, 2022
The effective treatment of cervical intraepithelial neoplasia (CIN) can prevent cervical cancer. Salvia miltiorrhiza is a medicinal and health-promoting plant. To identify a potential treatment for CIN, the effect of S.
Xuejiao Leng, Hongfei Kan, Qinhang Wu, Cunyu Li, Yunfeng Zheng, Guoping Peng   +5 more
doaj   +1 more source

Alleviatory Effects of Danshen, Salvianolic Acid A and Salvianolic Acid B on Pc12 Neuronal Cells and Drosophila Melanogaster Model of Alzheimer’s Disease [PDF]

Journal of Ethnopharmacology, 2020
Abstract Background: Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder worldwide. Its pathogenesis involves the hallmark aggregation of amyloid-beta (Aβ). Of all the Aβ oligomers formed in the brain, Aβ42 has been found to be the most toxic and aggressive.
Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam   +5 more
openaire   +2 more sources