Results 31 to 40 of about 114,392,668 (203)

Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots

Journal of Advanced Research, 2020
Salvia miltiorrhiza Bunge is an herb rich in bioactive tanshinone and salvianolic acid compounds. It is primarily used as an effective medicine for treating cardiovascular and cerebrovascular diseases.
Xiaolong Hao, Zhongqiang Pu, Gang Cao, Dawei You, Yang Zhou, Changping Deng, Min Shi, Shivraj Hariram Nile, Yao Wang, Wei Zhou, Guoyin Kai   +10 more
doaj   +1 more source

Salvianolic acid B attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction via Nrf2-Gpx4 pathway-mediated ferroptosis

Di-san junyi daxue xuebao, 2022
Objective To determine the improving effect of salvianolic acid B on renal interstitial fibrosis (RIF) of rats with unilateral ureteral obstruction (UUO) based on ferroptosis mediated by nuclear factor erythroid 2-related factor 2 (Nrf2)-glutathione ...
SUN Yuanbo, SONG Yanran, WANG Shiqi, SUN Lixin, LI Guiqin   +4 more
doaj   +1 more source

Alleviatory Effects of Danshen, Salvianolic Acid A and Salvianolic Acid B on Pc12 Neuronal Cells and Drosophila Melanogaster Model of Alzheimer’s Disease [PDF]

Journal of Ethnopharmacology, 2020
Abstract Background: Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder worldwide. Its pathogenesis involves the hallmark aggregation of amyloid-beta (Aβ). Of all the Aβ oligomers formed in the brain, Aβ42 has been found to be the most toxic and aggressive.
Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam   +5 more
openaire   +2 more sources

Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids of Salvia miltiorrhiza Roots (Danshen)

Frontiers in Pharmacology, 2022
Phenolic acids are cardiovascular constituents (originating from the Chinese medicinal herb Salvia miltiorrhiza root/Danshen) of DanHong and many other Danshen-containing injections.
Jun-Lan Lu, Jun-Lan Lu, Xue-Shan Zeng, Xue-Shan Zeng, Xin Zhou, Xin Zhou, Jun-Ling Yang, Jun-Ling Yang, Jun-Ling Yang, Ling-Ling Ren, Ling-Ling Ren, Xin-Yu Long, Xin-Yu Long, Feng-Qing Wang, Olajide E. Olaleye, Nan-Nan Tian, Nan-Nan Tian, Ya-Xuan Zhu, Ya-Xuan Zhu, Jia-Jia Dong, Wei-Wei Jia, Chuan Li, Chuan Li, Chuan Li   +23 more
doaj   +1 more source

Inhibition Effects of Salvianolic Acid M and Rosmarinic Acid in Salvia deserta Schang on Human Aldose Reductase [PDF]

, 2020
[Objectives] This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase (AR).
WU, Jie, WANG, Xinling, HE, Qian, YANG, Jian   +3 more
core   +1 more source

Recent Advances in Transcription Factor-Mediated Regulation of Salvianolic Acid Biosynthesis in Salvia miltiorrhiza. [PDF]

Plants (Basel)
Salvia miltiorrhiza Bunge is a traditional Chinese medicinal plant whose roots are rich in water-soluble phenolic acids. Rosmarinic acid and salvianolic acid B are representative components that confer antibacterial, antioxidant, and cardio ...
Chen S, Peng F, Tao S, Wan X, Liao H, Wang P, Yuan C, Mao C, Zhao X, Zhang C, He B, Zhong M.   +11 more
europepmc   +2 more sources

Salvianolic acid-A induces apoptosis, mitochondrial membrane potential loss and DNA damage in small cell lung cancer cell lines [PDF]

, 2015
Purpose: To examine the anticancer effect of salvianolic acid-A against human small cell lung cancer (SCLC) cells (H-69).Methods: In vitro antiproliferative effect of salvianolic acid against SCLC cell lines was evaluated by 3-(4,5-dimethylthiazol-2-yl ...
Guan, Y, Li, X-M, Li, J, Wang, L-Q, Wang, D-F   +4 more
core   +1 more source

Comparative Pharmacokinetics of Hydrophilic Components in Salvia miltiorrhiza Bge. and Carthamus tinctorius L. in Rats That Underwent Cerebral Ischemia Reperfusion Using an HPLC-DAD Method

Frontiers in Pharmacology, 2020
BackgroundIn China, the combination of herb Salvia miltiorrhiza Bge. (Danshen) and Carthamus tinctorius L. (Honghua) is an effective treatment for stroke.
Xixi Zhao, Li Yu, Yulin Chen, Yu Wang, Haitong Wan, Jiehong Yang   +5 more
doaj   +1 more source

Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial

Frontiers in Pharmacology, 2023
Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy.
Junlin Cheng, Jun Long, Jingjing Zhang, Le Han, Yunfang Hu, Jianghui Liu, Runze Qiu, Zhibin Zhu, Hongwei Fan   +8 more
doaj   +1 more source

DataSheet2_Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection.XLSX

, 2023
Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by enterovirus (EV) infection. EV71 is one of the major pathogens causing hand, foot, and mouth disease and is more likely to cause exacerbation and death than other ...
Sai Shi (10644074), Sheng Ye (453834), Hailong An (650610), Sen Ma (2558092), Yaxin Wang (638534), Binghong Xu (14702947), Lei Xie (61344)   +6 more
core   +1 more source