Results 41 to 50 of about 19,711 (218)

Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial

Frontiers in Pharmacology, 2023
Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy.
Junlin Cheng, Jun Long, Jingjing Zhang, Le Han, Yunfang Hu, Jianghui Liu, Runze Qiu, Zhibin Zhu, Hongwei Fan   +8 more
doaj   +1 more source

Tissue-smashing based ultra-rapid extraction of chemical constituents in herbal medicines [PDF]

, 2014
postprin
Chen, C, Fan, Y, Li, P, Qi, LW, So, KF, Yan, CP   +5 more
core   +1 more source

Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms

Frontiers in Pharmacology, 2022
Breast cancer is one of the most deadly malignancies in women worldwide. Salvia miltiorrhiza, a perennial plant that belongs to the genus Salvia, has long been used in the management of cardiovascular and cerebrovascular diseases.
Huan Zhao, Bing Han, Xuan Li, Chengtao Sun, Yufei Zhai, Man Li, Mi Jiang, Weiping Zhang, Yi Liang, Guoyin Kai   +9 more
doaj   +1 more source

Melissa officinalis L. decoctions as functional beverages: a bioactive approach and chemical characterization [PDF]

, 2015
Lemon balm (Melissa officinalis L.) is a member of the Lamiaceae family with a long story of human consumption. It has been consumed for decades, directly in food and as a decoction or an infusion for its medicinal purposes.
Barros, Lillian, Calhelha, Ricardo C., Carocho, Márcio, Ferreira, Isabel C.F.R., Morales, Patricia, Santos-Buelga, Celestino, Soković, Marina, Ćirić, Ana   +7 more
core   +1 more source

First total synthesis of salvianolic acid C, tournefolic acid A, and tournefolal [PDF]

Arkivoc, 2012
First total synthesis of the natural product salvianolic acid C, tournefolal and tournefolic acid A has been described. The key benzofuran skeletons are prepared via selective iodination and Sonogashira reaction.
Si-Da Shen, Gui-Ping Zhang, Min Lei, Li-Hong Hu   +3 more
openaire   +2 more sources

Comparative Pharmacokinetics of Hydrophilic Components in Salvia miltiorrhiza Bge. and Carthamus tinctorius L. in Rats That Underwent Cerebral Ischemia Reperfusion Using an HPLC-DAD Method

Frontiers in Pharmacology, 2020
BackgroundIn China, the combination of herb Salvia miltiorrhiza Bge. (Danshen) and Carthamus tinctorius L. (Honghua) is an effective treatment for stroke.
Xixi Zhao, Li Yu, Yulin Chen, Yu Wang, Haitong Wan, Jiehong Yang   +5 more
doaj   +1 more source

Dissection of the mechanism of traditional Chinese medical prescription-Yiqihuoxue formula as an effective anti-fibrotic treatment for systemic sclerosis [PDF]

, 2014
BACKGROUND: Systemic sclerosis (SSc) is a connective tissue fibrotic disease for which there is no effective treatment. Traditional Chinese Medicine (TCM), such as the Yiqihuoxue formula used in Shanghai TCM-integrated Hospital, has shown the efficacy of
Dongdong Chen, Haiyan Chu, Hejian Zou, Jin Yuan, Jiucun Wang, Li Jin, Ling Yu, Mengmeng Song, Qingmei Liu, Ting Wu, Wenyu Wu, Wenzhen Tu, Xiaodong Zhou, Yanyun Ma   +13 more
core   +2 more sources

Synthesis of SMND-309, a derivate of salvianolic acid B

Synthetic Communications, 2017
(E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl) acrylic acid, designated SMND-309, was synthesized starting from 2-hydroxy-3-methoxybenzaldehyde in 12 steps and with an overall yield of 44%. The synthetic key features were the conversion of aryl aldehyde into aryl acetic acid for one-carbon extended, the Perkin condensation ...
Wu, Kong, Song, Chan, Cui, Dong-Mei, Zhang, Chen   +3 more
openaire   +1 more source

EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway

Acta Pharmaceutica Sinica B, 2013
Salvianolic acids, including salvianolic acid A (SAA) and salvianolic acid B (SAB), are the main water-soluble bioactive compounds isolated from the Chinese medicinal herb Danshen and have been shown to exert in vitro and in vivo cardiovascular ...
Shoubao Wang, Weiku Zhang, Xiaobin Pang, Li Li, Guorong He, Xiuying Yang, Lianhua Fang, Juntian Zhang, Guanhua Du   +8 more
doaj   +1 more source

Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration [PDF]

, 2017
Neurodegenerative conditions remain difficult to treat, with the continuing failure to see therapeutic research successfully advance to clinical trials. One of the obstacles that must be overcome is to develop enhanced models of disease.
Cameron, GW, Drake, RA, Lee-Reeves, C, Loughlin, AJ, O'Rourke, C, Phillips, JB   +5 more
core   +3 more sources