Results 51 to 60 of about 17,886 (173)

Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male Mice

Frontiers in Pharmacology, 2021
Background: Salvianolic acid A (Sal A), a natural polyphenolic compound extracted from Radix Salvia miltiorrhiza (Danshen), exhibits exceptional pharmacological activities against cardiovascular diseases.
Jianfei Lai, Jianfei Lai, Qianyu Qian, Qianyu Qian, Qinchao Ding, Qinchao Ding, Qinchao Ding, Li Zhou, Ai Fu, Zhongyan Du, Cui Wang, Cui Wang, Zhenyuan Song, Songtao Li, Songtao Li, Xiaobing Dou, Xiaobing Dou   +16 more
doaj   +1 more source

Synthesis of SMND-309, a derivate of salvianolic acid B

Synthetic Communications, 2017
(E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl) acrylic acid, designated SMND-309, was synthesized starting from 2-hydroxy-3-methoxybenzaldehyde in 12 steps and with an overall yield of 44%. The synthetic key features were the conversion of aryl aldehyde into aryl acetic acid for one-carbon extended, the Perkin condensation ...
Wu, Kong, Song, Chan, Cui, Dong-Mei, Zhang, Chen   +3 more
openaire   +1 more source

First Synthesis of Shimobashiric Acid C With Acetonide as the Catechol Protecting Group

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
ABSTRACT Shimobashiric acid C (SBA‐C) shows excellent hyaluronidase inhibition but its natural isolation yield is only 0.0092 %. We report its first synthesis via a convergent seven‐step route from caffeic and rosmarinic acids in 35% overall yield.
Ruwen Li, Zhe Zhang, Pengshu Xu, Lin Zhou, Lei Chen, Zhongqiang Liu   +5 more
wiley   +1 more source

Cloning and characterization of a putative R2R3 MYB transcriptional repressor of the rosmarinic acid biosynthetic pathway from Salvia miltiorrhiza.

PLoS ONE, 2013
Salvia miltiorrhiza Bunge is one of the most renowned traditional medicinal plants in China. Phenolic acids that are derived from the rosmarinic acid pathway, such as rosmarinic acid and salvianolic acid B, are important bioactive components in S ...
Shuncang Zhang, Pengda Ma, Dongfeng Yang, Wenjing Li, Zongsuo Liang, Yan Liu, Fenghua Liu   +6 more
doaj   +1 more source

The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus

Emerging Microbes and Infections, 2020
Staphylococcus aureus (S. aureus), especially methicillin-resistant Staphylococcus aureus (MRSA), is a major cause of pneumonia, resulting in severe morbidity and mortality in adults and children.
Dan Mu, Yongxin Luan, Lin Wang, Zeyuan Gao, Panpan Yang, Shisong Jing, Yanling Wang, Hua Xiang, Tiedong Wang, Dacheng Wang   +9 more
doaj   +1 more source

Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction [PDF]

EBioMedicine, 2018
Salvia miltiorrhiza is used extensively to treat cardiovascular diseases. SAA is a major bioactive component in Salvia miltiorrhiza and mediates myocardial ischemia (MI). However, the industrial production of SAA is limited due to low yields. In addition, the direct targets of SAA are unknown.
Zhong, Weilong, Sun, Bo, Gao, Wenqing, Qin, Yuan, Zhang, Heng, Huai, Longcong, Tang, Yuanhao, Liang, Yuan, He, Lingfei, Zhang, Xiaoyun, Tao, Honglian, Chen, Shuang, Yang, Wei, Yang, Lan, Liu, Yanrong, Liu, Huijuan, Zhou, Honggang, Sun, Tao, Yang, Cheng   +18 more
openaire   +2 more sources

Experimental and theoretical assessment of salvianolic acid B, ellagic acid, and phorbol esters as drug candidates against breast and prostate cancer

Discover Chemistry
Global efforts to develop innovative anti-cancer lead compounds from natural compounds found in plants have gained advanced momentum, focusing on achieving Sustainable Development Goal (SDG) number 3 on good health and well-being.
Russell B. O. Ouma, Usama Raza, Silas M. Ngari, Joshua K. Kibet, Uzair Nisar, Muhammad Waqar Ali   +5 more
doaj   +1 more source

Astragalus Salvia Granules to Benefit the Qi (Qishen Yiqi Keli) protects H9C2 cardiomyocytes by suppressing oxidative stress

Journal of Traditional Chinese Medical Sciences, 2016
Objective: To investigate the effects of Qishen Yiqi Keli (QSYQ; Astragalus Salvia Granules to Benefit the Qi) on ROS scavenging and inhibition of NADPH oxidase in an effort to identify new natural antioxidants.
Bangze Fu, Shuzhen Guo, Xue Yu, Hong Chang, Wei Wang   +4 more
doaj   +1 more source

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts

ChemistryOpen, Volume 15, Issue 10, October 2026.
S. heldreichiana and S. tomentosa can be considered as effective sources of natural bioactive agents for further in vivo pharmacological evaluation and development. The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses.
Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay   +9 more
wiley   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 54, 28 September 2026.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source