Results 61 to 70 of about 929,762 (263)

First total synthesis of salvianolic acid C, tournefolic acid A, and tournefolal [PDF]

open access: yesArkivoc, 2012
First total synthesis of the natural product salvianolic acid C, tournefolal and tournefolic acid A has been described. The key benzofuran skeletons are prepared via selective iodination and Sonogashira reaction.
Si-Da Shen   +3 more
openaire   +2 more sources

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice

open access: yesFrontiers in Pharmacology, 2020
Background: Salvianolic acid A (Sal A), a natural polyphenol compound extracted from Radix Salvia miltiorrhiza (known as Danshen in China), possesses a variety of potential pharmacological activities.
Songtao Li   +9 more
semanticscholar   +1 more source

Synthesis of SMND-309, a derivate of salvianolic acid B

open access: yesSynthetic Communications, 2017
(E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl) acrylic acid, designated SMND-309, was synthesized starting from 2-hydroxy-3-methoxybenzaldehyde in 12 steps and with an overall yield of 44%. The synthetic key features were the conversion of aryl aldehyde into aryl acetic acid for one-carbon extended, the Perkin condensation ...
Wu, Kong   +3 more
openaire   +1 more source

EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway

open access: yesActa Pharmaceutica Sinica B, 2013
Salvianolic acids, including salvianolic acid A (SAA) and salvianolic acid B (SAB), are the main water-soluble bioactive compounds isolated from the Chinese medicinal herb Danshen and have been shown to exert in vitro and in vivo cardiovascular ...
Shoubao Wang   +8 more
doaj   +1 more source

Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity [PDF]

open access: yesPhytomedicine, 2014
Salvianolic acid A (Sal A), an important constituent of Radix Salviae Miltiorrhizae (RSM), is effective for the treatment of myocardial infarction (MI) and coronary heart disease due to its potential in the improvement of acute myocardial ischemia. However, its content is very low in RSM.
Hongrui, Xia   +3 more
openaire   +2 more sources

Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2

open access: yesOxidative Medicine and Cellular Longevity, 2020
Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy (DPN). Antioxidant strategies have been most widely explored; nevertheless, whether antioxidants alone prevent DPN still remains inconclusive. In the present study,
Chun-yang Xu   +9 more
semanticscholar   +1 more source

Rosemary extracts in functional foods: extraction, chemical characterization and incorporation of free and microencapsulated forms in cottage cheese [PDF]

open access: yes, 2016
Consumers search for food with functional characteristics beyond its nutritional properties. Thus, the concept of functional food has become a hot topic, allowing us to obtain additional health benefits, including disease prevention.
Barreiro, M.F.   +5 more
core   +1 more source

Elucidating the influence of gold nanoparticles on the binding of salvianolic acid B and rosmarinic acid to bovine serum albumin.

open access: yesPLoS ONE, 2015
Salvianolic acid B and rosmarinic acid are two main water-soluble active ingredients from Salvia miltiorrhiza with important pharmacological activities and clinical applications. The interactions between salvianolic acid B (or rosmarinic acid) and bovine
Xin Peng   +4 more
doaj   +1 more source

Phenolic profiles of cultivated, in vitro cultured and commercial samples of Melissa officinalis L. infusions [PDF]

open access: yes, 2013
Melissa officinalis L. (lemon balm) is normally consumed as infusions and presents therapeutic properties such as sedative, carminative and antispasmodic, being also included in some pharmaceutical preparations. The phenolic profiles of different samples
Barros, Lillian   +5 more
core   +1 more source

Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways

open access: yesDrug Design, Development and Therapy, 2019
Background: Liver fibrosis occurs due to chronic liver disease due to multiple pathophysiological causes. The main causes for this condition are chronic alcohol abuse, nonalcoholic steatohepatitis, and infection due to hepatitis C virus. Currently, there
Rong Wang   +5 more
semanticscholar   +1 more source

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