Results 71 to 80 of about 929,762 (263)

Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats [PDF]

Scientific Reports, 2015
AbstractNephrotic syndrome (NS) is still a therapeutic challenge. To date there is no ideal treatment. Evidence suggest that multidrug therapy has more effect than monotherapy in amelioration of renal injury. Salvianolic acid A (SAA) is the major active component of Salviae Miltio2rrhizae Bunge.
Hua-Ying Fan, Ming-Yan Yang, Dong Qi, Zuo-Kai Zhang, Lin Zhu, Xiu-Xin Shang-Guan, Ke Liu, Hui Xu, Xin Che   +8 more
openaire   +2 more sources

Application of targeted liposomes-based salvianolic acid A for the treatment of ischemic stroke

Neurotherapeutics
Novel therapeutics for the treatment of ischemic stroke remains to be the unmet clinical needs. Previous studies have indicated that salvianolic acid A (SAA) is a promising candidate for the treatment of the brain diseases. However, SAA has poor absolute
Ming-Yan Yang, Yu Liu, Ya-Wen Yu, Bai-Fang Gong, Jian Ruan, H. Fan   +5 more
semanticscholar   +1 more source

Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model [PDF]

Acta Pharmacologica Sinica, 2016
The current therapeutic approaches have a limited effect on the dysregulated pulmonary vascular remodeling, which is characteristic of pulmonary arterial hypertension (PAH). In this study we examined whether salvianolic acid A (SAA) extracted from the traditional Chinese medicine 'Dan Shen' attenuated vascular remodeling in a PAH rat model, and ...
Yu-Cai, Chen, Tian-Yi, Yuan, Hui-Fang, Zhang, Dan-Shu, Wang, Yu, Yan, Zi-Ran, Niu, Yi-Huang, Lin, Lian-Hua, Fang, Guan-Hua, Du   +8 more
openaire   +2 more sources

In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

Drug Design, Development and Therapy, 2021
Yun-Hong Wang,1 Tong Qu,2 Xue-Lian Wang,3 Rong-Ping Yang3 1Chongqing Academy of Chinese Materia Medica, Chongqing, 400065, People’s Republic of China; 2Shaanxi University of Chinese Medicine, Xianyang, 712046, People’s Republic of China ...
Wang YH, Qu T, Wang XL, Yang RP
doaj  

Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI

Journal of Pharmaceutical Analysis, 2022
Salvia miltiorrhiza Bge (SMB) has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases. Growing clinical usage has led to a huge demand for artificial planting of SMB.
Chenglong Sun, Li Cui, Bingqian Zhou, Xiao Wang, Lanping Guo, Wei Liu   +5 more
doaj   +1 more source

Development of a Multienzyme Cascade for Salvianolic Acid A Synthesis from l-Tyrosine. [PDF]

ACS Omega
Salvianolic acid A (SAA) has an important application value for preventing and treating cardiovascular diseases. In this study, we developed a novel multienzyme cascade system for the efficient biosynthesis of SAA, utilizing l-tyrosine (l-Tyr) as a cost-effective and stable starting material. The cascade system incorporated four enzymes: membrane-bound
Zhang M, Zhong J, Zhang Y, Wang W, Zhao W, Hu S, Lv C, Huang J, Mei L.   +8 more
europepmc   +4 more sources

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode [PDF]

, 2012
The electronic version of this article is the complete one and can be found online at: http://www.translational-medicine.com/content/10/1/26 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http ...
Guo-An Luo, Hong-Yang Zhang, Jun Wu, Qing-Bo Xu, Qing-Li Zhang, Qing-Zhong Xiao, Qiong-Lin Liang, Rong Gao, Rong-Li Zhang, Shu-Feng Lv, Xi Chen, Xiao-Ping Liang, Xue Li, Xue-Mei Fan, Yi-Jun Cheng, Yi-Ming Wang, Yuan-Yuan Xie   +16 more
core   +2 more sources

Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways

Drug Design, Development and Therapy, 2020
Introduction Osteoarthritis (OA), a chronic joint disease, combines with massive inflammation and plays a vital role in cartilage degeneration. The main strategy in clinic is controlling inflammation, thereby treating osteoarthritis.
Shuang Feng, H. Cong, Lei Ji
semanticscholar   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source