Results 201 to 210 of about 710,140 (248)

Salvianolic acid B protects against UVB-induced HaCaT cell senescence and skin aging through NRF2 activation and ROS scavenging.

Journal of Photochemistry and Photobiology. B: Biology
BACKGROUND Prolonged sunlight exposure can cause skin photoaging. The epidermis, the outermost layer of the skin, protects the body from the environment.
Jia-Ming Sun, Yuxin Liu, Yi-Tung Tsai, Yang-Dan Liu, Chiakang Ho, Dongsheng Wen, Tingyu Tsai, Dan-Ning Zheng, Ya Gao, Yifan Zhang, Li Yu   +10 more
semanticscholar   +1 more source

Pharmacological manipulation of Ezh2 with Salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy.

Pharmacological Research, 2022
Tumor vasculature is characterized by aberrant structure and function, resulting in immune suppressive profiles of tumor microenvironment (TME) through limiting immune cell infiltration into tumors. The defective vascular perfusion in tumors also impairs
C. Qian, Chunmei Yang, Yu Tang, Weiwei Zheng, Yueke Zhou, Shan Zhang, Mengyao Song, Peng Cheng, Zhonghong Wei, Chongjin Zhong, Li Wan, Aiyun Wang, Yang Zhao, Yin Lu   +13 more
semanticscholar   +1 more source

Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs

Archives of Pharmacal Research, 2009
Salvianolic acid B (SalB) is an active component isolated from Chinese herbal medicine Salvia miltiorrhiza. The aim of this study was to investigate the extent of absolute oral bioavailability (F) of SalB in beagle dogs and the effect on blood viscosity after intravenous and oral administration of Salvianolic acids (SAs). A gradient elution HPLC method
Dong-Yan, Gao, Li-Mei, Han, Li-Hong, Zhang, Xiao-Ling, Fang, Jian-Xin, Wang   +4 more
openaire   +2 more sources

Quaternized chitosan/Salvianolic acid B multifunctional hydrogel with ROS/glucose dual responsive properties for diabetic wound healing.

Carbohydrate Polymers
Diabetic wounds (DW) represent one of the most severe and persistent complications of diabetes, whose healing process is hindered by excessive accumulation of reactive oxygen species (ROS), dysregulated inflammation, and abnormal macrophage polarization.
Yanping Li, Xin Wang, Chenjiao Miao, Miao Song, Zheng Cao   +4 more
semanticscholar   +1 more source

Tree thorns-inspired hyaluronic acid-based dissolving microneedles loaded with salvianolic acid B for effective hypertrophic scar treatment with enhanced long-term stability.

Carbohydrate Polymers
Hypertrophic scar (HS) represents a natural consequence of abnormal fibroproliferation occurring during wound healing, which not only leads to tissue dysfunction but also causes psychological issues for patients.
Bricard Mbituyimana, Longjun Luo, Fuyu Qi, Yuchi Jiang, O. Atta, M. Kishta, Mostafa Maboruk, Min Wu, Wei Ge, Zhijun Shi, Guang Yang   +10 more
semanticscholar   +1 more source

Chemical conversions of salvianolic acid B by decoction in aqueous solution

Fitoterapia, 2012
Salvianolic acid B (Sal B) is the most abundant phenolic compound in Salvia miltiorrhiza, which has been widely used for the treatment of cardiovascular diseases in Oriental medicine. To elucidate structure of the converted compounds of Sal B by decoction in aqueous solution, Sal B (200 mg) was decocted in an aqueous solution (200 mL) at pH 4.9 and the
Hyoung Jae, Lee, Jeong-Yong, Cho, Jae-Hak, Moon   +2 more
openaire   +2 more sources

Bioavailability of salvianolic acid B in conscious and freely moving rats

International Journal of Pharmaceutics, 2006
Salvianolic acid B is an herbal ingredient isolated from Salvia miltiorrhiza. The aim of this study was to apply an automated blood sampling system coupled to a simple liquid chromatographic system to determine the bioavailability of salvianolic acid B in stress-free rats.
Yu-Tse, Wu, Yen-Fei, Chen, Yen-Ju, Hsieh, Ine, Jaw, Ming-Shi, Shiao, Tung-Hu, Tsai   +5 more
openaire   +2 more sources

Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.

Phytomedicine
BACKGROUND Prolonged exposure to sun radiation may result in harmful skin photoaging. Therefore, discovering novel anti-photoaging treatment modalities is critical.
Jia-Ming Sun, Yuxin Liu, Yang-Dan Liu, Chiakang Ho, Yi-Tung Tsai, Dongsheng Wen, Lu Huang, Dan-Ning Zheng, Ya Gao, Yifan Zhang, Li Yu   +10 more
semanticscholar   +1 more source

An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction.

Biomaterials, 2021
Drug-loaded hydrogels can improve blood supply and inhibit extracellular matrix degradation after myocardial infarction. However, due to the continual dynamic motion of cardiac tissue, the hydrogel structure cannot be reconstructed in time, causing ...
Rui Chen, Chenqi Zhu, Liu Xu, Yi-huang Gu, Shujing Ren, H. Bai, Qin Zhou, Xin Liu, Sheng-feng Lu, Xiao-lin Bi, Weidong Li, X. Jia, Zhipeng Chen   +12 more
semanticscholar   +1 more source

[Protective mechanism of salvianolic acid B on blood vessels].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023
Salvianolic acid B(Sal B) is the main water-soluble component of Salvia miltiorrhiza Bunge. Studies have found that Sal B has a good protective effect on blood vessels. Sal B can protect endothelial cells by anti-oxidative stress, inducing autophagy, inhibiting endoplasmic reticulum stress(ERS), inhibiting endothelial inflammation and adhesion molecule
Chun-Kun, Yang, Qing-Quan, Pan, Zhuang, Tian, Yan-Jun, DU, Feng-Qin, Sun, Jin, Lu, Jun, Li   +6 more
openaire   +1 more source