Results 211 to 220 of about 710,140 (248)

Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3.

Phytomedicine
BACKGROUND Mitochondrial ROS (mtROS) accumulation and NLRP3 inflammasome activation are critical in the pathogenesis of myocardial ischemia-reperfusion injury (MIRI).
Xiaohong Wei, Jie Chen, Xuefen Wu, Qian Zhang, Gui-Yang Xia, Xinyu Chu, Huan Xia, Sheng Lin, Hongcai Shang   +8 more
semanticscholar   +1 more source

Current progress of research on pharmacologic actions of salvianolic acid B

Chinese Journal of Integrative Medicine, 2012
As one of the main water-soluble composites of Radix Salviae, salvianolic acid B is a phenolic acid ingredient of the Chinese drug, which is rich content in the herb and has strong pharmaceutical activity. It is used to treat cardiocerebral vascular diseases, antagonize hepatic/renal fibrosis, prevent cancer, and promote stem cell proliferation and ...
Wei, Cao, Xiao-Wen, Guo, Hu-Zhan, Zheng, De-Ping, Li, Guan-Bo, Jia, Jie, Wang   +5 more
openaire   +2 more sources

ROS responsive conductive microspheres loaded with salvianolic acid B as adipose derived stem cell carriers for acute myocardial infarction treatment.

Biomaterials
Stem cell therapy is currently the most promising strategy for the treatment of myocardial infarction. However, the development of injectable cell carriers that can scavenge reactive oxygen species (ROS) in the infarct zone to improve transplanted cell ...
Lei Mu, Ruonan Dong, Congye Li, Jiangwei Chen, Ying Huang, Tongyang Li, Baolin Guo   +6 more
semanticscholar   +1 more source

Salvianolic acid B improves motor function after cerebral ischemia in rats

Behavioural Pharmacology, 2006
In a previous short-term study, salvianolic acid B was reported to have a protective effect on cerebral ischemia. Here, we investigated whether salvianolic acid B improves the recovery of motor function after cerebral ischemia in a 14-day investigation. Cerebral ischemia was induced by middle cerebral artery occlusion in rats.
Minke, Tang, Weihong, Feng, Yan, Zhang, Jing, Zhong, Juntian, Zhang   +4 more
openaire   +2 more sources

Phospholipids of inhaled liposomes determine the in vivo fate and therapeutic effects of salvianolic acid B on idiopathic pulmonary fibrosis.

Journal of Controlled Release
Since phospholipids have an important effect on the size, surface potential and hardness of liposomes that decide their in vivo fate after inhalation, this research has systematically evaluated the effect of phospholipids on pulmonary drug delivery by ...
Jianqing Peng, Qin Wang, Runbin Sun, Ke Zhang, Yi Chen, Zipeng Gong   +5 more
semanticscholar   +1 more source

Nano-delivery of salvianolic acid B induces the quiescence of tumor-associated fibroblasts via interfering with TGF-β1/Smad signaling to facilitate chemo- and immunotherapy in desmoplastic tumor.

International journal of pharmaceutics, 2022
As the key stromal cells that mediate the desmoplastic reaction, tumor-associated fibroblasts (TAFs) play a critical role in the limited nanoparticle penetration and suppressive immune tumor microenvironment.
Yunna Chen, Mengru Hu, Siwei Wang, Qiang Wang, Huiyu Lu, Fengling Wang, Lei Wang, D. Peng, Weidong Chen   +8 more
semanticscholar   +1 more source

Salvianolic acid B ameliorates hepatic fibrosis via inhibiting p300/CBP

European Journal of Pharmacology
Salvianolic acid B (Sal B), an active ingredient extracted from Salvia miltiorrhiza Bunge, has shown hepatic anti-fibrotic activity. Hepatic stellate cells (HSCs) activation is considered the determining event in liver fibrogenesis. E1A binding protein p300 (p300)/CREB binding protein (CBP) is an attractive target for inhibiting HSCs activation.
Lili Li, Huabiao Zhou, Miaomiao Li, Wenbo Liu, Yuxuan Li, Hanyang Xu, Jiemei Jiang, Yan Yang, Yongfang Gong   +8 more
openaire   +2 more sources

Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro

Aesthetic Plastic Surgery, 2023
Hypertrophic scars (HTSs) are a fibroproliferative disorder that occur following skin injuries. Salvianolic acid B (Sal-B) is an extractant from Salvia miltiorrhiza that has been reported to ameliorate fibrosis in multiple organs. However, the antifibrotic effect on HTSs remains unclear. This study aimed to determine the antifibrotic effect of Sal-B in
Chio-Hou, Chong, Jia-Ming, Sun, Yu-Xin, Liu, Yi-Tung, Tsai, Dan-Ning, Zheng, Yi-Fan, Zhang, Li, Yu   +6 more
openaire   +2 more sources

Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response.

Toxicology and Applied Pharmacology
AIMS Septic cardiomyopathy is characterized by impaired contractile function and mitochondrial activity dysregulation. Salvianolic acid B (Sal B) is a potent therapeutic compound derived from the traditional Chinese medicine Salvia miltiorrhiza.
Renshan Chen, Anran Zheng, Yunjing Wang, Liyou Guo, Huaqian Dou, Liangyan Lu, Muhammad Rafiq, Peihua Li, Xiuhui Chen, Qing Xiao   +9 more
semanticscholar   +1 more source

Immunomodulatory effects of Salvianolic acid B in a spontaneous abortion mouse model

Journal of Reproductive Immunology, 2020
Pregnancy is a kind of natural immune tolerance. Immune factors play an important role in recurrent spontaneous abortion and repeated implantation failure. Salvianolic acid B (SalB) has anti-tumor, anti-inflammatory, anti-oxidation and immunomodulatory functions.
Jing, Wang, Chi, Liu, Weitao, Que, Masayuki, Fujino, Guoqing, Tong, Hua, Yan, Xiao-Kang, Li   +6 more
openaire   +2 more sources