Results 81 to 90 of about 667,703 (231)

The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice [PDF]

International Journal of Molecular Sciences, 2015
Our previous study indicated that the combination of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1), the main components of Salvia miltiorrhizae and Panax notoginseng, improves myocardium structure and ventricular function in rats with ischemia/reperfusion injury.
Qun Zhao, Min Yang, Yanping Deng, Haitao Yu, Linlin Wang, Fukang Teng, Kenka Cho, Hongmei Ma, Peng Wu, Xue Li, Wanying Wu, Xuan Liu, Feng Xu, Baohong Jiang, De-An Guo   +14 more
openaire   +2 more sources

Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid hemorrhage

Frontiers in Immunology, 2023
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated immuno-inflammatory response plays a critical role in exacerbating early brain injury (EBI) after subarachnoid hemorrhage ...
Dayong Xia, Jinlong Yuan, Degang Wu, Haibin Dai, Zhuang Zong   +4 more
semanticscholar   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

3D bioprinting of Salvianolic acid B-sodium alginate-gelatin skin scaffolds promotes diabetic wound repair via antioxidant, anti-inflammatory, and proangiogenic effects.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
In patients with diabetic wounds, wound healing is impaired due to the presence of persistent oxidative stress, an altered inflammatory response, and impaired angiogenesis and epithelization.
Qin Lihao, Tingting Liu, Jiawei Zhang, Bai Yifei, Tang Zheyu, Jingyan Li, T. Xue, Z. Jia   +7 more
semanticscholar   +1 more source

EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway

Acta Pharmaceutica Sinica B, 2013
Salvianolic acids, including salvianolic acid A (SAA) and salvianolic acid B (SAB), are the main water-soluble bioactive compounds isolated from the Chinese medicinal herb Danshen and have been shown to exert in vitro and in vivo cardiovascular ...
Shoubao Wang, Weiku Zhang, Xiaobin Pang, Li Li, Guorong He, Xiuying Yang, Lianhua Fang, Juntian Zhang, Guanhua Du   +8 more
doaj   +1 more source

Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin [PDF]

Scientific Reports, 2017
AbstractSalvianolic acid B is an antioxidative ingredient derived from Radix Salviae miltiorrhizae that has been widely used to treat liver diseases. However, the therapeutic mechanism underlying Salvianolic acid B has remained largely unknown. Our studies verified that Salvianolic acid B efficiently blocked mitochondrial deformation and dysfunction ...
Yunxia Liu, Yingying Hu, Qiukai E, Ji Zuo, Ling Yang, Wen Liu   +5 more
openaire   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Neuroprotective mechanism of salvianolic acid B against cerebral ischemia–reperfusion injury in mice through downregulation of TLR4, p‐p38MAPK, p‐JNK, NF‐κB, and IL‐1β

Immunity, Inflammation and Disease, 2023
Tissue injury and inflammation are two potential outcomes of cerebral ischemia–reperfusion (I/R) injury. Salvianolic acid B (Sal B), isolated from the roots of Salvia miltiorrhiza, is one of the major water‐soluble compounds with a wide range of ...
Xiu-Fen Zheng, Xiang-jian Zhang, Lipeng Dong, Jing-Ru Zhao, Cong Zhang, Rong Chen   +5 more
semanticscholar   +1 more source

Salvianolic acid B inhibited high glucose-induced endothelial-mesenchymal transition through a down-regulation of β-catenin

Linchuang shenzangbing zazhi, 2021
Objective To explore the role of salvianolic acid B during phenotypic transition of endothelial cells induced by high glucose and elucidate the possible mechanism of β-catenin pathway.Methods Human umbilical vein endothelial cells were divided into 3 ...
Jing Ran, Li Ying-ying, Li Xiao-ping, Zhang Wan-fen, Feng Li-ping, Liu Tong-qiang   +5 more
doaj  

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source