Results 71 to 80 of about 19,334 (212)

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway

Acta Pharmaceutica Sinica B, 2013
Salvianolic acids, including salvianolic acid A (SAA) and salvianolic acid B (SAB), are the main water-soluble bioactive compounds isolated from the Chinese medicinal herb Danshen and have been shown to exert in vitro and in vivo cardiovascular ...
Shoubao Wang, Weiku Zhang, Xiaobin Pang, Li Li, Guorong He, Xiuying Yang, Lianhua Fang, Juntian Zhang, Guanhua Du   +8 more
doaj   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network

PLoS ONE, 2011
Targeting cellular function as a system rather than on the level of the single target significantly increases therapeutic potency. In the present study, we detect the target pathway of salvianolic acid B (SalB) in vivo. Acute myocardial infarction (AMI) was induced in rats followed by the treatment with 10 mg/kg SalB.
Lingling Xu, Yanping Deng, Lixin Feng, Defang Li, Xiaoyan Chen, Chao Ma, Xuan Liu, Jun Yin, Min Yang, Fukang Teng, Wanying Wu, Shuhong Guan, Baohong Jiang, Dean Guo   +13 more
openaire   +4 more sources

Mentha spicata L. infusions as sources of antioxidant phenolic compounds: emerging reserve lots with special harvest requirements [PDF]

, 2016
Mentha spicata L., commonly known as spearmint, is widely used in both fresh and dry forms, for infusion preparation or in European and Indian cuisines.
Barros, Lillian, Ferreira, Isabel C.F.R., Pereira, Carla, Rita, Íngride, Santos-Buelga, Celestino   +4 more
core   +1 more source

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Salvianolic acid B inhibited high glucose-induced endothelial-mesenchymal transition through a down-regulation of β-catenin

Linchuang shenzangbing zazhi, 2021
Objective To explore the role of salvianolic acid B during phenotypic transition of endothelial cells induced by high glucose and elucidate the possible mechanism of β-catenin pathway.Methods Human umbilical vein endothelial cells were divided into 3 ...
Jing Ran, Li Ying-ying, Li Xiao-ping, Zhang Wan-fen, Feng Li-ping, Liu Tong-qiang   +5 more
doaj  

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves) [PDF]

, 2016
The chemical composition and bioactive properties of two plants (Calendula officinalis L. and Mentha cervina L.) were studied. Their nutritional value revealed a high content of carbohydrates and low fat levels, and very similar energy values.
Barros, Lillian, Calhelha, Ricardo C., Castro, María Ángeles, Ferreira, Isabel C.F.R., Garcia, Pablo A., Miguel, María, Pereira, Carla, Santos-Buelga, Celestino   +7 more
core   +1 more source

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1‐Driven Raf‐ERK Pathway Activation Promotes Cardiomyocyte Mitosis

MedComm, Volume 7, Issue 5, May 2026.
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Ce Cao, Bo Ma, Jian Zhang, Lili Yang, Zixin Liu, Haoran Li, Jianshu Song, Keer Zhang, Lei Li, Jianhua Fu, Jianxun Liu   +10 more
wiley   +1 more source