Results 11 to 20 of about 828,082 (149)

Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics [PDF]

Molecules, 2018
For drugs with high hydrophilicity and poor membrane permeability, absorption enhancers can promote membrane permeability and improve oral bioavailability. Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) is a new kind of absorption enhancer that has
Ying Li, Dandan Yang, Chunyan Zhu
doaj   +3 more sources

Recent Advances in Transcription Factor–Mediated Regulation of Salvianolic Acid Biosynthesis in Salvia miltiorrhiza [PDF]

Plants
Salvia miltiorrhiza Bunge is a traditional Chinese medicinal plant whose roots are rich in water-soluble phenolic acids. Rosmarinic acid and salvianolic acid B are representative components that confer antibacterial, antioxidant, and cardio ...
Song Chen, Fang Peng, Shan Tao, Xiufu Wan, Hailang Liao, Peiyuan Wang, Can Yuan, Changqing Mao, Xinyi Zhao, Chao Zhang, Bing He, Mingzhi Zhong   +11 more
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Post-Harvest Induced Production of Salvianolic Acids and Significant Promotion of Antioxidant Properties in Roots of Salvia miltiorrhiza (Danshen)

Molecules, 2014
Danshen, the dried roots of Salvia miltiorrhiza, is an extremely valued Traditional Chinese Medicine. Previously, we have demonstrated that salvianolic acid B (SaB), the important bioactive ingredient in this herb, was a post-harvest product.
Guo-Jun Zhou, Wei Wang, Xiao-Mei Xie, Min-Jian Qin, Ben-Ke Kuai, Tong-Shui Zhou   +5 more
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The Effect of Salvia tomentosa Miller Extracts, Rich in Rosmarinic, Salvianolic and Lithospermic Acids, on Bacteria Causing Opportunistic Infections

Molecules
Methanolic-aqueous extracts of Salvia tomentosa Miller roots, aerial parts, and inflorescences were examined for their content of polyphenolic derivatives and the antimicrobial and cytotoxic effect.
Ewelina Piątczak, Joanna Kolniak-Ostek, Weronika Gonciarz, Paweł Lisiecki, Urszula Kalinowska-Lis, Magdalena Szemraj, Magdalena Chmiela, Sylwia Zielińska   +7 more
doaj   +2 more sources

The therapeutic effects of salvianolic acids on ischemic stroke: From molecular mechanisms to clinical applications

Pharmacological Research
Ischemic stroke (IS), primarily caused by cerebrovascular occlusion, poses a significant public health challenge with limited effective therapeutic options.
Chao Zhao, Xiaodan Bai, Aidong Wen, Jingwen Wang, Yi Ding   +4 more
doaj   +2 more sources

Neuroprotective effects of salvianolic acids combined with Panax notoginseng saponins in cerebral ischemia/reperfusion rats concerning the neurovascular unit and trophic coupling [PDF]

Brain and Behavior
Background The neurovascular unit (NVU) and neurovascular trophic coupling (NVTC) play a key regulatory role in brain injury caused by ischemic stroke.
Hongyang Chen, Zhen Liu, Lei Zhao, Zhuangzhuang Jia   +3 more
doaj   +2 more sources

Inhibition of Melanoma Cell Growth by Salvianolic Acid A through CHK2-CDC25A Pathway Modulation

Frontiers in Bioscience-Landmark
Background: This study investigated the impact of salvianolic acids, derived from Danshen, on melanoma cell growth. Specifically, we assessed the ability of salvianolic acid A (Sal A) to modulate melanoma cell proliferation.
Xiao-Yan Pu, Yonghong Mei, Qiang Zheng, Chih-Yuan Ko   +3 more
doaj   +2 more sources

Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants

Molecules, 2015
A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which ...
Gabriela López-Frías, Alejandro A. Camacho-Dávila, David Chávez-Flores, Gerardo Zaragoza-Galán, Víctor H. Ramos-Sánchez   +4 more
doaj   +2 more sources

First Synthesis of Shimobashiric Acid C With Acetonide as the Catechol Protecting Group. [PDF]

Chem Biodivers
ABSTRACT Shimobashiric acid C (SBA‐C) shows excellent hyaluronidase inhibition but its natural isolation yield is only 0.0092 %. We report its first synthesis via a convergent seven‐step route from caffeic and rosmarinic acids in 35% overall yield.
Li R, Zhang Z, Xu P, Zhou L, Chen L, Liu Z.   +5 more
europepmc   +2 more sources

Plant-Derived Polyphenol Salvianolic Acid B Attenuates Cardiomyocyte Pyroptosis by Modulating the MMP12-NLRP3 Signaling Axis. [PDF]

Food Sci Nutr
HG induces MMP12 upregulation in AC16 cardiomyocytes, which activates the NLRP3 inflammasome, triggers GSDMD‐mediated pyroptosis, and promotes the release of inflammatory cytokines. Sal B alleviates cardiomyocyte damage by modulating MMP12, while MMP12 overexpression abrogates this protective effect.
Xie Z, Yang ZK, Zheng L, Wu P, Chen S, Ye X, Gao Y.   +6 more
europepmc   +2 more sources