Results 21 to 30 of about 828,082 (149)

Integrative Phytochemical, Antioxidant, and NLRP3-Linked and Anti-Inflammatory Evaluation of Salvia balansae (Aurès Chemotype): Insights Into Its Safety and Therapeutic Potential. [PDF]

ChemistryOpen
An endemic Aurès chemotype of Salvia balansae emerges as a rich source of luteolin, rosmarinic acid, and other polyphenols with potent antioxidant and NLRP3‐linked anti‐inflammatory activities. Protection against experimental inflammation, favorable enzyme‐modulating properties, and a wide safety margin highlight its promise as a pharmaceutical and ...
Bendrihem KA, Hachemi M, Mihoubi MA, Amine FM, Sharifi-Rad M, Houhou D, Guemmaz R, Kherraz K, Zeraib A, Abdelmalek A, Mouane A, Ayeb NE, Bensuici C, Chikha M, Nagaz K, Atoki AV, Messaoudi M.   +16 more
europepmc   +2 more sources

Aqueous Incubation Reveals Transformation of Rosmarinic Acid in Medicinally Important Nepetoideae Species and Leads to Novel Bioactive Compounds [PDF]

Pharmaceutics
Background: Rosmarinic acid (RA) is a major phenylpropanoid constituent of many medicinal plants belonging to the Nepetoideae subfamily of the Lamiaceae family and contributes significantly to their biological activities.
Adila Nazli, Bernadett Szögi-Tatár, Szilvia Bősze, Gergő Tóth, Katalin Solymosi, Szabolcs Béni, Imre Boldizsár   +6 more
doaj   +2 more sources

Temporal Phenolic Profile and Bioactivity of Endemic Salvia transsylvanica (Transylvanian Sage) During Flowering [PDF]

Antioxidants
Salvia transsylvanica, an endemic Romanian sage, remains understudied despite co-occurrence with validated medicinal Salvia species. In this study, leaves and flowers were harvested weekly during flowering (May and June) and subjected to classical ...
Maria-Doroteia Brudiu, Alexandru Nicolescu, Beatriz H. Paschoalinotto, Maria Inês Dias, Gianina Crișan, Andrei Mocan   +5 more
doaj   +2 more sources

Targeting post-stroke neuroinflammation with Salvianolic acid A: molecular mechanisms and preclinical evidence [PDF]

Frontiers in Immunology
Salvianolic acid A (SalA), a bioactive compound extracted from Salvia miltiorrhiza, has garnered considerable interest for its potential in ameliorating the post-stroke neuroinflammation.
Hongchun Yang, Muhammad Mustapha Ibrahim, Muhammad Mustapha Ibrahim, Siyu Zhang, Siyu Zhang, Yao Sun, Yao Sun, Junlei Chang, Junlei Chang, Hui Qi, Shilun Yang, Shilun Yang   +11 more
doaj   +2 more sources

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y₁ and P2Y₁₂ receptors. [PDF]

Sci Rep, 2018
Many hemorheologic Traditional Chinese Medicines (TCMs) that are widely-used clinically lack molecular mechanisms of action. We hypothesized that some of the active components of hemorheologic TCMs may function through targeting prothrombotic P2Y1 and/or
Liu X, Gao ZG, Wu Y, Stevens RC, Jacobson KA, Zhao S.   +5 more
europepmc   +2 more sources

Anti-atherosclerotic effects and molecular targets of salvianolic acids from <i>Salvia miltiorrhiza</i> Bunge. [PDF]

Front Pharmacol
Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is a traditional Chinese medication used extensively as a therapeutic agent against atherosclerosis (AS) because of its substantial cardiovascular protective properties as well
Liang Q, Liu X, Xu X, Chen Z, Luo T, Su Y, Xie H, Gao H, Xie C.   +8 more
europepmc   +2 more sources

Molecular Pharmacology of Rosmarinic and Salvianolic Acids: Potential Seeds for Alzheimer's and Vascular Dementia Drugs. [PDF]

Int J Mol Sci, 2018
Both caffeic acid and 3,4-dihydroxyphenyllactic acid (danshensu) are synthesized through two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the rosemary and sage family of Lamiaceae, these two compounds are joined ...
Habtemariam S.
europepmc   +2 more sources

Neuroprotective Effect of Salvianolic Acids against Cerebral Ischemia/Reperfusion Injury. [PDF]

Int J Mol Sci, 2016
This study investigated the neuroprotective effect of salvianolic acids (SA) against ischemia/reperfusion (I/R) injury, and explored whether the neuroprotection was dependent on mitochondrial connexin43 (mtCx43) via the phosphatidylinositol 3-kinase ...
Hou S, Hou S, Zhao MM, Shen PP, Liu XP, Sun Y, Feng JC.   +6 more
europepmc   +2 more sources

Protective Effect of Natural Phenolic Acids, Rosmarinic Acid and Salvianolic Acid, Against Diabetic Atherosclerosis. [PDF]

Int J Mol Sci
Cardiovascular disease (CVDs) and atherosclerosis remain a major causes of morbidity and mortality worldwide. Endothelial dysfunction is a central driver of atherosclerosis, which is significantly accelerated in diabetes mellitus through hyperglycemia ...
Won Y, Kim HJ.
europepmc   +2 more sources

Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. [PDF]

Nutrients
Silymarin, salvianolic acids B, and puerarin were considered healthy food agents with tremendous potential to ameliorate non-alcoholic fatty liver disease (NAFLD).
Wang X, Jin Y, Di C, Zeng Y, Zhou Y, Chen Y, Pan Z, Li Z, Ling W.   +8 more
europepmc   +2 more sources