Results 71 to 80 of about 11,816 (210)

Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants

Molecules, 2015
A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which ...
Gabriela López-Frías, Alejandro A. Camacho-Dávila, David Chávez-Flores, Gerardo Zaragoza-Galán, Víctor H. Ramos-Sánchez   +4 more
doaj   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease:A Review [PDF]

, 2018
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium.
Chen, Xing, Guo, Dongqing, Jiao, Shihong, Liu, Tianhua, Murdoch, Colin E., Qu, Jia, Wang, Wei, Wang, Yong   +7 more
core   +3 more sources

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1‐Driven Raf‐ERK Pathway Activation Promotes Cardiomyocyte Mitosis

MedComm, Volume 7, Issue 5, May 2026.
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Ce Cao, Bo Ma, Jian Zhang, Lili Yang, Zixin Liu, Haoran Li, Jianshu Song, Keer Zhang, Lei Li, Jianhua Fu, Jianxun Liu   +10 more
wiley   +1 more source

Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin [PDF]

Scientific Reports, 2017
AbstractSalvianolic acid B is an antioxidative ingredient derived from Radix Salviae miltiorrhizae that has been widely used to treat liver diseases. However, the therapeutic mechanism underlying Salvianolic acid B has remained largely unknown. Our studies verified that Salvianolic acid B efficiently blocked mitochondrial deformation and dysfunction ...
Yunxia Liu, Yingying Hu, Qiukai E, Ji Zuo, Ling Yang, Wen Liu   +5 more
openaire   +2 more sources

Decoction, infusion and hydroalcoholic extract of cultivated thyme : antioxidant and antibacterial activities, and phenolic characterisation [PDF]

, 2015
Bioactivity of thyme has been described, but mostly related to its essential oils, while studies with aqueous extracts are scarce. Herein, the antioxidant and antibacterial properties of decoction, infusion and hydroalcoholic extract, as also their ...
Barros, Lillian, Ferreira, Isabel C. F. R., Henriques, Mariana, Martins, Natália, Santos-Buelga, Celestino, Silva, Sónia Carina   +5 more
core   +2 more sources

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Inhibition of Melanoma Cell Growth by Salvianolic Acid A through CHK2-CDC25A Pathway Modulation

Frontiers in Bioscience-Landmark
Background: This study investigated the impact of salvianolic acids, derived from Danshen, on melanoma cell growth. Specifically, we assessed the ability of salvianolic acid A (Sal A) to modulate melanoma cell proliferation.
Xiao-Yan Pu, Yonghong Mei, Qiang Zheng, Chih-Yuan Ko   +3 more
doaj   +1 more source

Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity [PDF]

Phytomedicine, 2014
Salvianolic acid A (Sal A), an important constituent of Radix Salviae Miltiorrhizae (RSM), is effective for the treatment of myocardial infarction (MI) and coronary heart disease due to its potential in the improvement of acute myocardial ischemia. However, its content is very low in RSM.
Hongrui, Xia, Longru, Sun, Hongxiang, Lou, M Mukhlesur, Rahman   +3 more
openaire   +2 more sources

The Effect of Salvia tomentosa Miller Extracts, Rich in Rosmarinic, Salvianolic and Lithospermic Acids, on Bacteria Causing Opportunistic Infections

Molecules
Methanolic-aqueous extracts of Salvia tomentosa Miller roots, aerial parts, and inflorescences were examined for their content of polyphenolic derivatives and the antimicrobial and cytotoxic effect.
Ewelina Piątczak, Joanna Kolniak-Ostek, Weronika Gonciarz, Paweł Lisiecki, Urszula Kalinowska-Lis, Magdalena Szemraj, Magdalena Chmiela, Sylwia Zielińska   +7 more
doaj   +1 more source