Results 71 to 80 of about 947,067 (264)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Quantum fluctuations approach to the nonequilibrium GW approximation

Condensed Matter Physics, 2022
The quantum dynamics of fermionic or bosonic many-body systems following external excitation can be successfully studied using two-time nonequilibrium Green's functions (NEGF) or single-time reduced density matrix methods.
E. Schroedter, J.-P. Joost, M. Bonitz
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integrated Two-Stage Optimization of Strategic Unmanned Aerial Vehicle Allocation and Operational Scheduling Under Demand Uncertainty

Applied Sciences
The rapid growth of e-commerce has intensified the need for efficient last-mile delivery, making unmanned aerial vehicles (UAVs) a promising solution. However, despite their potential, practical deployment remains limited by how to effectively plan depot
Xiaojin Zheng, Shengkun Qin, Yanxia Zhang, Jiazhen Huo   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Strategic Fleet Planning Under Carbon Tax and Fuel Price Uncertainty: An Integrated Stochastic Model for Fleet Deployment and Speed Optimization

Mathematics
This paper presents a two-stage stochastic programming model for the joint optimization of fleet deployment and sailing speed in liner shipping under fuel price volatility and carbon tax uncertainty.
Weilin Sun, Ying Yang, Shuaian Wang
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

On Robust Optimal Joint Deployment and Assignment of RAN Intelligent Controllers in O-RANs

IEEE Open Journal of the Communications Society
The open radio access network (O-RAN) architecture is consolidating the concept of software-defined cellular networks beyond 5G networks, mainly through the introduction of the near-real-time radio access network (RAN) intelligent controller (Near-RT RIC)
Mohammad J. Abdel-Rahman, Emadeldin A. Mazied, Fahid Hassan, Kory Teague, Allen B. Mackenzie, Scott F. Midkiff, Kleber V. Cardoso, Dimitrios S. Nikolopoulos   +7 more
doaj   +1 more source

Last Mile Delivery With Stochastic Travel Times Considering Dual Services

IEEE Access, 2019
Nowadays there are two prevailing delivery modes in the last mile delivery; one is the home delivery (HD) that vehicles deliver parcels to customers' homes; and the other is the customers' pickup (CP) that vehicle deliver parcels to some kind of ...
Fuli Zhou, Yandong He, Lin Zhou
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source