Results 181 to 190 of about 2,022,785 (307)

A One Health investigation of a Crimean-Congo Hemorrhagic fever outbreak reveals high seropositivity in livestock in Lyantonde District, Uganda, 2024. [PDF]

One Health
Nyakarahuka L, Mulei S, Whitmer SL, Mutesi J, Baluku J, Torach CR, Namanya D, Tumusiime A, Kyondo J, Telford CT, Schuh A, Montgomery JM, Lutwama JJ, Balinandi SK, Shoemaker TR.   +14 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Trajectory Landscapes for Therapeutic Strategy Design in Agent-Based Tumor Microenvironment Models. [PDF]

IEEE Control Syst Lett
Cramer E, Heiser LM, Chang YH.
europepmc   +1 more source

Abtastregelung (Sampled Data Control) [PDF]

Journal of Dynamic Systems, Measurement, and Control, 1973
Ju¨rgen Ackermann, R. Isermann
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Sampled-data fuzzy [Formula: see text] estimators for control of nonlinear parabolic partial differential equations. [PDF]

Sci Rep
Sivakumar M, Dharani S, Cao J.
europepmc   +1 more source

Sampled-data stabilization for Takagi-Sugeno fuzzy systems using membership function deviations

, 2012
This paper is concerned with sampled-data stabilization for Takagi-Sugeno (T-S) fuzzy systems by using the property of membership function deviations.
Qing-Long Han (9801650), XB Chi (9877967), Xin-Chun Jia (9807830)   +2 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Influence of time of day and insecticide treatment on the abundance of Culiseta melanura (Diptera: Culicidae) in resting boxes. [PDF]

J Med Entomol
Brown N, Keven JB, Walker ED.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source