Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Seroprevalence and Factors Associated with <i>Toxoplasma gondii</i> Seropositivity in Small Ruminants in Northeastern Portugal. [PDF]
Animals (Basel)Pereira T +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Hybrid Intrusion Detection System with Real-Time Concept Drift Detection for Enhanced IoT Security. [PDF]
Sensors (Basel)Obaidat MA, Abouali M, Shakeel A.
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Computational blueprint and stereochemical validation of a small peptide derived from <i>Lacticaseibacillus casei</i> VITCM05 targeting estrogen receptor alpha and human epidermal growth factor receptor 2. [PDF]
Front BioinformShree Kumari GR, Vaithilingam M.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Assessing the effectiveness of the patient referral system in remote Zambia: A case study of Mbala District. [PDF]
Afr J Prim Health Care Fam MedDolopo A.
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Subunit-dependent interfacial assembly of wheat gliadin subunits by <i>Lycium barbarum</i> polysaccharide underlies foam stabilization. [PDF]
Food Chem XLi C, Wang B, Yu HY, Dai XL, Yang T.
europepmc +1 more source