Results 81 to 90 of about 374,310 (266)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Observer‐Based Sampled‐Data Controller in Saturated Systems via Composite Nonlinear Feedback
Engineering ReportsEmploying composite nonlinear feedback idea, an observer‐based digital controller is addressed for continuous‐time systems with input nonlinearity and disturbance. To achieve the regulation purpose, the equivalent discrete‐time equations are obtained via
Valiollah Ghaffari +3 more
doaj +1 more source
IEEE AccessThis paper is an attempt to extend the theory of positive systems to sampled-data systems. Even though where to take the initial time is unimportant in positivity of linear time-invariant systems, this is not the case for sampled-data systems because of ...
Ryosuke Shiga +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Advances in Mechanical Engineering, 2016 This article investigates the sampled-data disturbance rejection control problem for a class of non-integral-chain systems with mismatched uncertainties.
Jun You +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Sampled-Data-Based Local Stability of Neutral Time-Delay Systems With Actuator Saturation
IEEE AccessIn this work, the local stability issue of neutral delay system with actuator saturation under sampled-data controller is studied. Firstly, considering the influence of actuator saturation on the system, the sampled-data controller with variable sampling
Dapeng Li, Shuiqing Ye, Chao Ge
doaj +1 more source