Results 71 to 80 of about 1,812,833 (310)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Characterization of frequency drift of sampled-grating DBR laser module under direct modulation [PDF]

open access: yes, 2008
The authors demonstrate the drift in frequency of a static sampled-grating distributed Bragg reflector (SG DBR) laser module when it is subjected to direct modulation.
Anandarajah, Prince M.   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Sampled-data based state and parameter estimation for state-affine systems with uncertain output equation

open access: yes, 2018
The problem of sampled-data observer design is addressed for a class of state- and parameter-affine nonlinear systems. The main novelty in this class lies in the fact that the unknown parameters enter the output equation and the associated regressor is ...
Schoukens, Maarten   +7 more
core   +1 more source

H ∞ and H 2 optimal sampled-data controller synthesis: A hybrid systems approach with mixed discrete/continuous specifications

open access: yes, 2021
In this paper, a tractable sampled-data controller synthesis method is proposed for linear time-invariant plants that gives guarantees for stability and performance of the closed-loop system in terms of the H ∞- and H 2-norm.
Donkers, M.C.F. (Tijs)   +1 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Sampled-data fuzzy controller for continuous nonlinear systems

open access: yes, 2008
The sampled-data fuzzy control of nonlinear systems is presented. The consequents of the fuzzy controller rules are linear sampled-data sub-controllers. As a result, the fuzzy controller is a weighted sum of some linear sampled-data sub-controllers that ...
Bingo Wing-Kuen Ling (14869390)   +1 more
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Home - About - Disclaimer - Privacy